node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPSY_0027 | BPSY_1639 | BPSY_0027 | BPSY_1639 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate synthase. | 0.430 |
BPSY_0027 | guaB | BPSY_0027 | BPSY_1175 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.930 |
BPSY_0027 | murD | BPSY_0027 | BPSY_1939 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.487 |
BPSY_0027 | murI | BPSY_0027 | BPSY_2036 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.922 |
BPSY_1206 | BPSY_1270 | BPSY_1206 | BPSY_1270 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Purl. | 0.794 |
BPSY_1206 | BPSY_1639 | BPSY_1206 | BPSY_1639 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate synthase. | 0.999 |
BPSY_1206 | glsA | BPSY_1206 | BPSY_0582 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutaminase; Belongs to the glutaminase family. | 0.780 |
BPSY_1206 | guaB | BPSY_1206 | BPSY_1175 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.443 |
BPSY_1206 | murI | BPSY_1206 | BPSY_2036 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.806 |
BPSY_1214 | murD | BPSY_1214 | BPSY_1939 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.611 |
BPSY_1214 | murG | BPSY_1214 | BPSY_1937 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.552 |
BPSY_1214 | murI | BPSY_1214 | BPSY_2036 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.807 |
BPSY_1270 | BPSY_1206 | BPSY_1270 | BPSY_1206 | Purl. | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.794 |
BPSY_1270 | BPSY_1639 | BPSY_1270 | BPSY_1639 | Purl. | Glutamate synthase. | 0.940 |
BPSY_1270 | guaB | BPSY_1270 | BPSY_1175 | Purl. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.948 |
BPSY_1270 | murD | BPSY_1270 | BPSY_1939 | Purl. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.754 |
BPSY_1270 | murI | BPSY_1270 | BPSY_2036 | Purl. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.772 |
BPSY_1639 | BPSY_0027 | BPSY_1639 | BPSY_0027 | Glutamate synthase. | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.430 |
BPSY_1639 | BPSY_1206 | BPSY_1639 | BPSY_1206 | Glutamate synthase. | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.999 |
BPSY_1639 | BPSY_1270 | BPSY_1639 | BPSY_1270 | Glutamate synthase. | Purl. | 0.940 |