STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa)    
Predicted Functional Partners:
rpoZ
DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
  
 0.972
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
 
 
 0.965
spoT
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.964
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.953
gpt
Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
  
 
 0.953
hpt
Similar to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt or stm0170 SWALL:HPRT_SALTY (SWALL:O33799) (178 aa) fasta scores: E(): 1.2e-54, 86.2% id in 174 aa, and to Escherichia coli, Escherichia coli O6, and Shigella flexneri hypoxanthine phosphoribosyltransferase Hpt or b0125 or c0154 or sf0122 SWALL:HPRT_ECOLI (SWALL:P36766) (178 aa) fasta scores: E(): 2.4e-54, 84.48% id in 174 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
  
 0.940
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.935
pykF
Pyruvate kinase; Similar to Escherichia coli, and Escherichia coli O157:H7 pyruvate kinase I PykF or b1676 or z2704 or ecs2383 SWALL:KPY1_ECOLI (SWALL:P14178) (470 aa) fasta scores: E(): 4.4e-139, 84.68% id in 470 aa.
 
 
 0.928
pykA
Pyruvate kinase II; Similar to Escherichia coli pyruvate kinase ii PykA or b1854 SWALL:KPY2_ECOLI (SWALL:P21599) (479 aa) fasta scores: E(): 2.7e-156, 91.23% id in 479 aa.
 
 
 0.926
ECA3005
Similar to Ralstonia solanacearum putative glutamine amidotransferase protein rsc0213 or rs00645 SWALL:Q8Y2W9 (EMBL:AL646058) (238 aa) fasta scores: E(): 9e-37, 45.37% id in 238 aa, and to Xylella fastidiosa GMP synthase xf0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 1.1e-28, 43.8% id in 242 aa.
  
 
 0.921
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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