STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tkrA2-ketogluconate reductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (321 aa)    
Predicted Functional Partners:
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.956
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.950
aceB
Similar to Escherichia coli malate synthase A AceB or Mas or b4014 SWALL:MASY_ECOLI (SWALL:P08997) (533 aa) fasta scores: E(): 6.4e-180, 82.04% id in 529 aa.
     
 0.947
aceA
Isocitrate lyase; Similar to Escherichia coli, and Escherichia coli O6 isocitrate lyase AceA or Icl or b4015 or c4972 SWALL:ACEA_ECOLI (SWALL:P05313) (434 aa) fasta scores: E(): 4.7e-157, 86.8% id in 432 aa.
   
 
 0.946
gloA
Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
   
 
 0.945
eda
Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri Khg/kdpg aldolase [includes: 4-hydroxy-2-oxoglutarate aldolase and 2- dehydro-3-deoxyphosphogluconate aldolase Eda or Hga or KdgA or b1850 or c2263 or z2902 or ecs2560 or sf1860 SWALL:ALKH_ECOLI (SWALL:P10177) (213 aa) fasta scores: E(): 1.2e-67, 89.15% id in 212 aa, and to Erwinia chrysanthemi khg/kdpg aldolase [includes: 4-hydroxy-2-oxoglutarate aldolase Eda or KdgA SWALL:ALKH_ERWCH (SWALL:P38448) (213 aa) fasta scores: E(): 7e-67, 89.2% id in 213 aa.
    
  0.945
garK
Glycerate kinase 2; Similar to Escherichia coli glycerate kinase 2 GarK or b3124 SWALL:GRK2_ECOLI (SWALL:P23524) (381 aa) fasta scores: E(): 6.4e-89, 70.5% id in 373 aa, and to Bacillus subtilis glycerate kinase GalxK or s14A SWALL:GRK_BACSU (SWALL:P42100) (382 aa) fasta scores: E(): 3.9e-78, 58.57% id in 379 aa; Belongs to the glycerate kinase type-1 family.
    
  0.944
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 
 0.930
hprA
Glycerate dehydrogenase; Similar to Methylobacterium extorquens glycerate dehydrogenase HprA SWALL:DHGY_METEX (SWALL:Q59516) (313 aa) fasta scores: E(): 9.9e-43, 42.03% id in 314 aa, and to Haemophilus influenzae putative 2-hydroxyacid dehydrogenase Hi1556 hi1556 SWALL:YF56_HAEIN (SWALL:P45250) (315 aa) fasta scores: E(): 6.7e-68, 55.06% id in 316 aa; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
 
  
 
0.908
ECA0824
Similar to Rhodospirillum rubrum pyruvate-flavodoxin oxidoreductase NifJ SWALL:NIFJ_RHORU (SWALL:Q53046) (1191 aa) fasta scores: E(): 0, 54.73% id in 1182 aa, and to Escherichia coli probable pyruvate-flavodoxin oxidoreductase ydbk or b1378 SWALL:NIFJ_ECOLI (SWALL:P52647) (1174 aa) fasta scores: E(): 0, 78.79% id in 1174 aa. Also similar to ECA2957 (47.377% id. in 1182 aa overlap).
  
 
 0.906
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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