STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
waaFSimilar to Escherichia coli ADP-heptose--LPS heptosyltransferase II RfaF or WaaF or b3620 SWALL:RFAF_ECOLI (SWALL:P37692) (348 aa) fasta scores: E(): 6.2e-108, 74.41% id in 344 aa, and to Serratia marcescens heptosyltransferase II WaaF SWALL:Q936B7 (EMBL:U52844) (348 aa) fasta scores: E(): 7e-115, 79.36% id in 344 aa. (355 aa)    
Predicted Functional Partners:
waaC
Similar to Escherichia coli lipopolysaccharide heptosyltransferase-1 RfaC or WaaC or Rfa-2 or b3621 SWALL:RFAC_ECOLI (SWALL:P24173) (319 aa) fasta scores: E(): 6.6e-89, 71.47% id in 319 aa, and to Serratia marcescens heptosyltransferase i WaaC SWALL:Q936B6 (EMBL:U52844) (321 aa) fasta scores: E(): 8.9e-98, 76.25% id in 320 aa.
 
0.999
waaG
Similar to Escherichia coli lipopolysaccharide core biosynthesis protein Rfag or WaaG or pcsa or b3631 SWALL:RFAG_ECOLI (SWALL:P25740) (374 aa) fasta scores: E(): 1.2e-87, 58.69% id in 368 aa, and to Salmonella typhimurium lipopolysaccharide core biosynthesis protein Rfag or WaaG or stm3722 SWALL:O68269 (EMBL:AF026386) (374 aa) fasta scores: E(): 1.5e-89, 60.05% id in 368 aa.
 
 
 0.990
waaQ
Similar to Escherichia coli lipopolysaccharide core biosynthesis glycosyl transferase RfaQ or WaaQ or b3632 SWALL:RFAQ_ECOLI (SWALL:P25742) (344 aa) fasta scores: E(): 1.3e-65, 52.69% id in 334 aa, and to Salmonella typhimurium lipopolysaccharide core biosynthesis, modification of heptose region of core RfaQ or stm3723 SWALL:O68270 (EMBL:AF026386) (344 aa) fasta scores: E(): 1.2e-64, 51.79% id in 334 aa.
 
 
0.987
kdtA
3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
  
 0.986
rfaD
ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
 
  
 0.983
ECA3523
Similar to Yersinia pestis hypothetical protein ypo1074 or y3103 SWALL:Q8ZH37 (EMBL:AJ414146) (188 aa) fasta scores: E(): 1.8e-57, 79.03% id in 186 aa, and to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri hypothetical protein yaed or b0200 or z0212 or ecs0202 or sf0191 SWALL:AAN41853 (EMBL:D15061) (191 aa) fasta scores: E(): 2.8e-57, 80.43% id in 184 aa.
  
 0.947
rfaE
ADP-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family.
 
  
 0.903
nuoC
NADH-quinone oxidoreductase chain C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family.
   
 
 0.892
waaL1
O-antigen ligase; Similar to Escherichia coli O-antigen ligase RfaL or WaaL or b3622 SWALL:RFAL_ECOLI (SWALL:P27243) (419 aa) fasta scores: E(): 1.2e-28, 29.22% id in 414 aa, and to Serratia marcescens lipid a core:surface polymer ligase WaaL SWALL:Q936B4 (EMBL:U52844) (413 aa) fasta scores: E(): 1.1e-39, 33.76% id in 385 aa. Also similar to ECA0161 (36.735% id. in 392 aa overlap).
  
 
 0.890
ECA0149
Similar to Yersinia pestis putative sugar transferase RafQ SWALL:Q8ZJC7 (EMBL:AJ414141) (326 aa) fasta scores: E(): 8.7e-82, 60.06% id in 323 aa, and to Serratia marcescens putative heptosyliii transferase WaaQ SWALL:Q9X979 (EMBL:U52844) (337 aa) fasta scores: E(): 7.2e-12, 26.23% id in 343 aa, and to Escherichia coli WaaQ SWALL:Q9R9D5 (EMBL:AF019746) (340 aa) fasta scores: E(): 3.2e-08, 23.25% id in 301 aa.
 
 
 0.834
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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