STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ECA0171Putative rhodanese-related sulfurtransferases; Similar to Yersinia pestis putative membrane protein ypo0065 SWALL:Q8ZJM9 (EMBL:AJ414141) (144 aa) fasta scores: E(): 1.2e-36, 69.78% id in 139 aa, and to Salmonella typhimurium, and Salmonella typhi YibN SWALL:Q8XEX1 (EMBL:AE008872) (143 aa) fasta scores: E(): 6e-34, 67.62% id in 139 aa, and to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 hypothetical protein YibN SWALL:YIBN_ECOLI (SWALL:P37688) (143 aa) fasta scores: E(): 1.8e-33, 66.18% id in 139 aa. (143 aa)    
Predicted Functional Partners:
dsbA
Similar to Erwinia carotovora thiol:disulfide interchange protein DsbA precursor SWALL:DSBA_ERWCA (SWALL:Q9RB10) (207 aa) fasta scores: E(): 1.2e-76, 98.55% id in 207 aa.
 
  
 0.699
atpF
ATP synthase B chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
  
    0.636
secB
Protein-export protein; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.
  
    0.617
smpA
Putative outer membrane lipopotein (small protein A); Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
    0.611
gpsA
Glycerol-3-phosphate dehydrogenase [NAD(P)+]; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri glycerol-3-phosphate dehydrogenase [NAD(P)+] GpsA or b3608 or c4430 or z5035 or ecs4486 or sf3647 SWALL:GPDA_ECOLI (SWALL:P37606) (339 aa) fasta scores: E(): 9.3e-104, 86.26% id in 335 aa; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
  
    0.579
lapB
Conserved hypothetical protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family.
  
     0.575
ECA0170
Putative exported peptidase; Similar to Yersinia pestis putative membrane protein y0078 SWALL:AAM83673 (EMBL:AE013608) (456 aa) fasta scores: E(): 2.5e-78, 71.87% id in 416 aa, and to Salmonella typhi hypothetical protein Sty4090 SWALL:Q8Z2F1 (EMBL:AL627280) (427 aa) fasta scores: E(): 9.5e-72, 67.49% id in 403 aa, and to Escherichia coli hypothetical protein YibP SWALL:YIBP_ECOLI (SWALL:P37690) (419 aa) fasta scores: E(): 3.5e-71, 66.5% id in 403 aa.
  
    0.565
grxA
Glutaredoxin 1; Similar to Escherichia coli, and Shigella flexneri glutaredoxin 1 GrxA or Grx or b0849 or sf0802 SWALL:GLR1_ECOLI (SWALL:P00277) (85 aa) fasta scores: E(): 6e-21, 69.88% id in 83 aa.
  
  
 0.562
tolB
TolB protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
  
     0.560
ECA0169
Putative exported protein; Similar to Salmonella typhimurium putative periplasmic protein YigQ or stm3706 SWALL:Q8ZL54 (EMBL:AE008872) (320 aa) fasta scores: E(): 3.9e-70, 66.01% id in 306 aa, and to Escherichia coli hypothetical protein YibQ precursor SWALL:YIBQ_ECOLI (SWALL:P37691) (319 aa) fasta scores: E(): 3.1e-68, 66.55% id in 293 aa.
       0.555
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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