STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
metRTranscriptional activator protein; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri transcriptional activator protein MetR or b3828 or z5349 or ecs4758 or sf3906 SWALL:METR_ECOLI (SWALL:P19797) (317 aa) fasta scores: E(): 7.2e-105, 85.8% id in 310 aa; Belongs to the LysR transcriptional regulatory family. (311 aa)    
Predicted Functional Partners:
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
 
  
 0.841
metE-2
5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Similar to Pseudomonas putida MetE SWALL:Q9AF89 (EMBL:AF363277) (361 aa) fasta scores: E(): 1.6e-114, 82.94% id in 340 aa, and to Agrobacterium tumefaciens 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase MetE or atu3823 or agr_l_2018 SWALL:Q8U9A5 (EMBL:AE009313) (342 aa) fasta scores: E(): 3.4e-124, 90.29% id in 340 aa.
 
  
 0.587
metF
Similar to Erwinia carotovora 5,10-methylenetetrahydrofolate reductase MetF SWALL:METF_ERWCA (SWALL:P71319) (298 aa) fasta scores: E(): 4.2e-114, 97.65% id in 298 aa, and to Escherichia coli, and Shigella flexneri 5,10-methylenetetrahydrofolate reductase MetF or b3941 or sf4019 SWALL:METF_ECOLI (SWALL:P00394) (296 aa) fasta scores: E(): 2.1e-101, 86.05% id in 294 aa.
   
  
 0.550
btuB
Vitamin B12 receptor precursor; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
   
  
 0.543
ECA4427
LysR-family transcriptional regulator; Similar to Agrobacterium tumefaciens regulatory protein NocR or atu6029 or agr_pti_70 SWALL:NOCR_AGRT5 (SWALL:Q00678) (300 aa) fasta scores: E(): 1.4e-28, 35.29% id in 289 aa, and to Rhizobium meliloti octopine catabolism/uptake operon regulatory protein OccR SWALL:OCCR_RHIME (SWALL:P72294) (297 aa) fasta scores: E(): 5.8e-23, 36.58% id in 287 aa; Belongs to the LysR transcriptional regulatory family.
  
     0.514
ECA0131
Similar to Pseudomonas aeruginosa probable transcriptional regulator pa5085 SWALL:Q9HU98 (EMBL:AE004921) (318 aa) fasta scores: E(): 9.5e-27, 36.15% id in 307 aa, and to Salmonella typhimurium, and Salmonella typhi positive transcriptional regulator LysR SWALL:Q8XGD5 (EMBL:AE008838) (311 aa) fasta scores: E(): 1.8e-15, 26.66% id in 300 aa, and to Escherichia coli transcriptional activator protein LysR SWALL:LYSR_ECOLI (SWALL:P03030) (311 aa) fasta scores: E(): 3.2e-13, 27.79% id in 277 aa; Belongs to the LysR transcriptional regulatory family.
  
     0.508
ECA0922
Similar to Pseudomonas syringae transcriptional regulator, LusR family pspto1618 SWALL:Q886G1 (EMBL:AE016861) (302 aa) fasta scores: E(): 2e-62, 53.53% id in 297 aa, and to Yersinia pestis putative transcriptional regulator mlr2579 SWALL:Q93AB4 (EMBL:AF426171) (303 aa) fasta scores: E(): 3.7e-44, 44.33% id in 300 aa; Belongs to the LysR transcriptional regulatory family.
  
     0.497
sftR
LysR-family transcriptional regulator; Similar to Pseudomonas putida SftR SWALL:Q9WWU4 (EMBL:AF126201) (304 aa) fasta scores: E(): 1.2e-43, 42.19% id in 301 aa, and to Pseudomonas sp. SDS degradation transcriptional activation protein sdsB SWALL:SDSB_PSES9 (SWALL:P52686) (306 aa) fasta scores: E(): 1.3e-30, 36.53% id in 312 aa; Belongs to the LysR transcriptional regulatory family.
  
     0.488
metJ
Repressor of the methionine regulon; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family.
   
  
 0.483
sulA
Cell division inhibitor; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
      
 0.481
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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