ECA0189 protein (Pectobacterium atrosepticum)

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ECA0189

Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function. (399 aa)

Predicted Functional Partners:

ECA0920

0.953

rspA

0.950

uxuA

0.949

uxaA

0.947

uxuB

0.947

kdgK

0.918

rpiB

0.902

gnd

0.902

rpiA

0.902

rpe

0.870

Your Current Organism:

Pectobacterium atrosepticum

NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ECA0189	ECA0920	ECA0189	ECA0920	Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.	Probable carbohydrate oxidoreductase; Similar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 1.5e-102, 54.83% id in 476 aa, and to Escherichia coli hypothetical oxidoreductase ydfi or b1542 SWALL:YDFI_ECOLI (SWALL:P77260) (486 aa) fasta scores: E(): 1.2e-127, 65.26% id in 475 aa. Also similar to ECA0819 (UxuB) (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family.	0.953
ECA0189	gnd	ECA0189	ECA1444	Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.	0.902
ECA0189	kdgK	ECA0189	ECA4360	Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.	2-dehydro-3-deoxygluconokinase; Similar to Erwinia chrysanthemi 2-dehydro-3-deoxygluconokinase KdgK SWALL:KDGK_ERWCH (SWALL:P45416) (310 aa) fasta scores: E(): 1.4e-100, 82.25% id in 310 aa.	0.918
ECA0189	rpe	ECA0189	ECA4089	Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.	Ribulose-phosphate 3-epimerase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri ribulose-phosphate 3-epimerase Rpe or Dod or b3386 or c4156 or z4739 or ecs4228 or sf3404 SWALL:RPE_ECOLI (SWALL:P32661) (225 aa) fasta scores: E(): 5.1e-71, 83.92% id in 224 aa.	0.870
ECA0189	rpiA	ECA0189	ECA3906	Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.	Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.	0.902
ECA0189	rpiB	ECA0189	ECA0863	Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.	Ribose 5-phosphate isomerase; Involved in catabolism of D-apiose. Catalyzes the isomerization of D-erythrulose 4-phosphate to D-erythrose 4-phosphate.	0.902
ECA0189	rspA	ECA0189	ECA0917	Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.	Putative starvation sensing mandelate racemase / muconate lactonizing enzyme; Similar to Escherichia coli starvation sensing protein RspA SWALL:RSPA_ECOLI (SWALL:P38104) (404 aa) fasta scores: E(): 5.7e-163, 92.57% id in 404 aa. Also similar to ECA0189 (36.070% id. in 402 aa overlap).	0.950
ECA0189	uxaA	ECA0189	ECA0647	Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.	Similar to Escherichia coli altronate hydrolase UxaA SWALL:UXAA_ECOLI (SWALL:P42604) (495 aa) fasta scores: E(): 4.1e-163, 80.24% id in 496 aa.	0.947
ECA0189	uxuA	ECA0189	ECA1093	Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.	Mannonate dehydratase; Catalyzes the dehydration of D-mannonate; Belongs to the mannonate dehydratase family.	0.949
ECA0189	uxuB	ECA0189	ECA0819	Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.	Similar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 4.5e-107, 56.03% id in 489 aa, and to Yersinia pestis putative D-mannonate oxidoreductase ypo1280 or y2903 SWALL:AAM86454 (EMBL:AJ414147) (490 aa) fasta scores: E(): 8.7e-128, 63.93% id in 488 aa. Also similar to ECA0920 (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family.	0.947
ECA0920	ECA0189	ECA0920	ECA0189	Probable carbohydrate oxidoreductase; Similar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 1.5e-102, 54.83% id in 476 aa, and to Escherichia coli hypothetical oxidoreductase ydfi or b1542 SWALL:YDFI_ECOLI (SWALL:P77260) (486 aa) fasta scores: E(): 1.2e-127, 65.26% id in 475 aa. Also similar to ECA0819 (UxuB) (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family.	Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.	0.953
ECA0920	kdgK	ECA0920	ECA4360	Probable carbohydrate oxidoreductase; Similar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 1.5e-102, 54.83% id in 476 aa, and to Escherichia coli hypothetical oxidoreductase ydfi or b1542 SWALL:YDFI_ECOLI (SWALL:P77260) (486 aa) fasta scores: E(): 1.2e-127, 65.26% id in 475 aa. Also similar to ECA0819 (UxuB) (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family.	2-dehydro-3-deoxygluconokinase; Similar to Erwinia chrysanthemi 2-dehydro-3-deoxygluconokinase KdgK SWALL:KDGK_ERWCH (SWALL:P45416) (310 aa) fasta scores: E(): 1.4e-100, 82.25% id in 310 aa.	0.501
ECA0920	rspA	ECA0920	ECA0917	Probable carbohydrate oxidoreductase; Similar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 1.5e-102, 54.83% id in 476 aa, and to Escherichia coli hypothetical oxidoreductase ydfi or b1542 SWALL:YDFI_ECOLI (SWALL:P77260) (486 aa) fasta scores: E(): 1.2e-127, 65.26% id in 475 aa. Also similar to ECA0819 (UxuB) (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family.	Putative starvation sensing mandelate racemase / muconate lactonizing enzyme; Similar to Escherichia coli starvation sensing protein RspA SWALL:RSPA_ECOLI (SWALL:P38104) (404 aa) fasta scores: E(): 5.7e-163, 92.57% id in 404 aa. Also similar to ECA0189 (36.070% id. in 402 aa overlap).	0.968
ECA0920	uxaA	ECA0920	ECA0647	Probable carbohydrate oxidoreductase; Similar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 1.5e-102, 54.83% id in 476 aa, and to Escherichia coli hypothetical oxidoreductase ydfi or b1542 SWALL:YDFI_ECOLI (SWALL:P77260) (486 aa) fasta scores: E(): 1.2e-127, 65.26% id in 475 aa. Also similar to ECA0819 (UxuB) (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family.	Similar to Escherichia coli altronate hydrolase UxaA SWALL:UXAA_ECOLI (SWALL:P42604) (495 aa) fasta scores: E(): 4.1e-163, 80.24% id in 496 aa.	0.712
ECA0920	uxuA	ECA0920	ECA1093	Probable carbohydrate oxidoreductase; Similar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 1.5e-102, 54.83% id in 476 aa, and to Escherichia coli hypothetical oxidoreductase ydfi or b1542 SWALL:YDFI_ECOLI (SWALL:P77260) (486 aa) fasta scores: E(): 1.2e-127, 65.26% id in 475 aa. Also similar to ECA0819 (UxuB) (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family.	Mannonate dehydratase; Catalyzes the dehydration of D-mannonate; Belongs to the mannonate dehydratase family.	0.989
ECA0920	uxuB	ECA0920	ECA0819	Probable carbohydrate oxidoreductase; Similar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 1.5e-102, 54.83% id in 476 aa, and to Escherichia coli hypothetical oxidoreductase ydfi or b1542 SWALL:YDFI_ECOLI (SWALL:P77260) (486 aa) fasta scores: E(): 1.2e-127, 65.26% id in 475 aa. Also similar to ECA0819 (UxuB) (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family.	Similar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 4.5e-107, 56.03% id in 489 aa, and to Yersinia pestis putative D-mannonate oxidoreductase ypo1280 or y2903 SWALL:AAM86454 (EMBL:AJ414147) (490 aa) fasta scores: E(): 8.7e-128, 63.93% id in 488 aa. Also similar to ECA0920 (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family.	0.944
gnd	ECA0189	ECA1444	ECA0189	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.	Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.	0.902
gnd	rpe	ECA1444	ECA4089	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.	Ribulose-phosphate 3-epimerase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri ribulose-phosphate 3-epimerase Rpe or Dod or b3386 or c4156 or z4739 or ecs4228 or sf3404 SWALL:RPE_ECOLI (SWALL:P32661) (225 aa) fasta scores: E(): 5.1e-71, 83.92% id in 224 aa.	0.985
gnd	rpiA	ECA1444	ECA3906	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.	Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.	0.983
gnd	rpiB	ECA1444	ECA0863	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.	Ribose 5-phosphate isomerase; Involved in catabolism of D-apiose. Catalyzes the isomerization of D-erythrulose 4-phosphate to D-erythrose 4-phosphate.	0.973

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