STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
birABira bifunctional protein [includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (319 aa)    
Predicted Functional Partners:
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
 
 0.948
murB
UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.
  
  
 0.943
tadA
Putative cytidine and deoxycytidylate deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
 
    0.941
ECA2374
Similar to Yersinia pestis hypothetical protein Ypo2072 SWALL:Q8ZET1 (EMBL:AJ414151) (232 aa) fasta scores: E(): 1.3e-62, 72.84% id in 232 aa, and to Escherichia coli hypothetical protease yeaz yeaz or b1807 SWALL:YEAZ_ECOLI (SWALL:P76256) (231 aa) fasta scores: E(): 2.8e-59, 69.13% id in 230 aa.
 
    0.935
accC
Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
 
 0.927
ECA1009
Similar to Rhodobacter sphaeroides biotin sulfoxide reductase SWALL:BISC_RHOSH (SWALL:P54934) (744 aa) fasta scores: E(): 6.3e-130, 48.13% id in 725 aa, and to Escherichia coli biotin sulfoxide reductase bisc or b3551 SWALL:BISC_ECOLI (SWALL:P20099) (777 aa) fasta scores: E(): 8.5e-72, 39.01% id in 751 aa; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
     
  0.900
ECA2142
Urea amidolyase; Similar to the C-terminal region of Saccharomyces cerevisiae urea amidolyase [includes: urea carboxylase and allophanate hydrolase] Dur1,2 or ybr208c or ybr1448 SWALL:DUR1_YEAST (SWALL:P32528) (1835 aa) fasta scores: E(): 0, 52.92% id in 1213 aa, and to Pseudomonas fluorescens urea amidolyase homologue uahA SWALL:Q9XAV3 (EMBL:AJ243652) (1213 aa) fasta scores: E(): 0, 51.47% id in 1224 aa.
 
  
 0.899
pcnB
poly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
 
  
 0.877
ECA1917
Putative allophanate hydrolase; Similar to the C-terminal region of Saccharomyces cerevisiae urea amidolyase [includes: urea carboxylase and allophanate hydrolase Dur1,2 or ybr208c or ybr1448 SWALL:DUR1_YEAST (SWALL:P32528) (1835 aa) fasta scores: E(): 3.6e-203, 44.47% id in 1212 aa, and to Caulobacter crescentus urea amidolyase-related protein cc1829 SWALL:Q9A797 (EMBL:AE005857) (1207 aa) fasta scores: E(): 0, 56.38% id in 1206 aa.
 
 0.857
xthA
Similar to Escherichia coli exodeoxyribonuclease III XthA or Xth or b1749 SWALL:EX3_ECOLI (SWALL:P09030) (268 aa) fasta scores: E(): 1.3e-87, 76.31% id in 266 aa.
  
    0.840
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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