STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiFThiamine biosynthesis adenylyltransferase; Similar to Escherichia coli adenylyltransferase ThiF or b3992 SWALL:THIF_ECOLI (SWALL:P30138) (251 aa) fasta scores: E(): 7e-59, 60.56% id in 246 aa. (259 aa)    
Predicted Functional Partners:
thiS
Thiamine biosynthesis protein; Similar to Escherichia coli this protein ThiS or ThiG1 or b3991.1 SWALL:THIS_ECOLI (SWALL:O32583) (66 aa) fasta scores: E(): 2.4e-12, 56.06% id in 66 aa.
 
 0.997
thiG
Thiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.984
thiH
Similar to Escherichia coli thiazole biosynthesis protein ThiH or b3990 SWALL:THIH_ECOLI (SWALL:P30140) (376 aa) fasta scores: E(): 2.6e-125, 81.03% id in 369 aa.
 
  
 0.978
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.970
thiC
Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
  
 0.969
thiI
Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
    
 0.945
moaE
Similar to Escherichia coli molybdopterin converting factor subunit 2 MoaE or ChlA5 or b0785 SWALL:MOAE_ECOLI (SWALL:P30749) (149 aa) fasta scores: E(): 6.1e-45, 76.51% id in 149 aa.
 
 0.883
moaD
Similar to Escherichia coli molybdopterin converting factor subunit 1 MoaD or ChlA4 or ChlM or b0784 SWALL:MOAD_ECOLI (SWALL:P30748) (81 aa) fasta scores: E(): 3.2e-19, 67.9% id in 81 aa.
  
 
 0.697
thiD
Similar to Escherichia coli phosphomethylpyrimidine kinase ThiD or b2103 SWALL:THID_ECOLI (SWALL:P76422) (266 aa) fasta scores: E(): 1.1e-78, 78.27% id in 267 aa.
 
  
 0.690
moeA
Molybdopterin biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.
  
 0.686
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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