STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiCThiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (664 aa)    
Predicted Functional Partners:
thiG
Thiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.996
thiD
Similar to Escherichia coli phosphomethylpyrimidine kinase ThiD or b2103 SWALL:THID_ECOLI (SWALL:P76422) (266 aa) fasta scores: E(): 1.1e-78, 78.27% id in 267 aa.
 
 
 0.995
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
 0.993
thiH
Similar to Escherichia coli thiazole biosynthesis protein ThiH or b3990 SWALL:THIH_ECOLI (SWALL:P30140) (376 aa) fasta scores: E(): 2.6e-125, 81.03% id in 369 aa.
 
  
 0.986
thiF
Thiamine biosynthesis adenylyltransferase; Similar to Escherichia coli adenylyltransferase ThiF or b3992 SWALL:THIF_ECOLI (SWALL:P30138) (251 aa) fasta scores: E(): 7e-59, 60.56% id in 246 aa.
 
  
 0.969
thiS
Thiamine biosynthesis protein; Similar to Escherichia coli this protein ThiS or ThiG1 or b3991.1 SWALL:THIS_ECOLI (SWALL:O32583) (66 aa) fasta scores: E(): 2.4e-12, 56.06% id in 66 aa.
  
  
 0.961
purM
Similar to Escherichia coli phosphoribosylformylglycinamidine cyclo-ligase PurM or PurG or b2499 SWALL:PUR5_ECOLI (SWALL:P08178) (344 aa) fasta scores: E(): 2.9e-117, 85.71% id in 343 aa.
     
 0.811
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
     
  0.800
moeB
Similar to Escherichia coli molybdopterin biosynthesis protein MoeB or ChlN or b0826 SWALL:MOEB_ECOLI (SWALL:P12282) (249 aa) fasta scores: E(): 1.1e-66, 71.37% id in 248 aa.
 
  
 0.699
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
  
  
 0.665
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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