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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Score
thiCThiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (664 aa)    
Predicted Functional Partners:
thiG
Thiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.998
thiD
Similar to Escherichia coli phosphomethylpyrimidine kinase ThiD or b2103 SWALL:THID_ECOLI (SWALL:P76422) (266 aa) fasta scores: E(): 1.1e-78, 78.27% id in 267 aa.
 
 
 0.998
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.997
thiH
Similar to Escherichia coli thiazole biosynthesis protein ThiH or b3990 SWALL:THIH_ECOLI (SWALL:P30140) (376 aa) fasta scores: E(): 2.6e-125, 81.03% id in 369 aa.
 
  
 0.996
thiF
Thiamine biosynthesis adenylyltransferase; Similar to Escherichia coli adenylyltransferase ThiF or b3992 SWALL:THIF_ECOLI (SWALL:P30138) (251 aa) fasta scores: E(): 7e-59, 60.56% id in 246 aa.
 
  
 0.990
thiS
Thiamine biosynthesis protein; Similar to Escherichia coli this protein ThiS or ThiG1 or b3991.1 SWALL:THIS_ECOLI (SWALL:O32583) (66 aa) fasta scores: E(): 2.4e-12, 56.06% id in 66 aa.
  
  
 0.985
purM
Similar to Escherichia coli phosphoribosylformylglycinamidine cyclo-ligase PurM or PurG or b2499 SWALL:PUR5_ECOLI (SWALL:P08178) (344 aa) fasta scores: E(): 2.9e-117, 85.71% id in 343 aa.
     
 0.946
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
     
  0.944
amtB
Probable ammonium transporter; Similar to Escherichia coli, and Escherichia coli O157:H7 probable ammonium transporter AmtB or b0451 or z0563 or ecs0505 SWALL:AMTB_ECOLI (SWALL:P37905) (428 aa) fasta scores: E(): 4.1e-125, 76.11% id in 427 aa.
      
 0.781
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
  
 
 0.739
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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