STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ECA0292Conserved hypothetical protein; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (188 aa)    
Predicted Functional Partners:
ECA0293
Similar to Yersinia pestis hypothetical protein ypo3577 SWALL:Q8ZB48 (EMBL:AJ414157) (328 aa) fasta scores: E(): 2e-101, 81.59% id in 326 aa, and to Escherichia coli hypothetical protein Yrbh SWALL:YRBH_ECOLI (SWALL:P45395) (328 aa) fasta scores: E(): 2e-95, 78.08% id in 324 aa.
 
 0.998
kdsA
2-dehydro-3-deoxyphosphooctonate aldolase; Similar to Escherichia coli, and Shigella flexneri 2-dehydro-3-deoxyphosphooctonate aldolase KdsA or b1215 or sf1218 SWALL:KDSA_ECOLI (SWALL:P17579) (284 aa) fasta scores: E(): 5.2e-99, 90.45% id in 283 aa; Belongs to the KdsA family.
  
 0.997
kdsB
3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
 
  
 0.994
ECA0289
ABC transporter, ATP-binding component; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri probable ABC transporter ATP-binding protein YhbG SWALL:AAN44707 (EMBL:D12938) (241 aa) fasta scores: E(): 2.5e-76, 90.87% id in 241 aa, and to Salmonella typhimurium, and Salmonella typhi putative ABC superfamily Yhbg SWALL:Q8XFR6 (EMBL:AE008852) (241 aa) fasta scores: E(): 1.1e-75, 90.04% id in 241 aa.
 
  
 0.929
lptC
Putative exported protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
  
 0.921
lptA
Putative exported protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
  
  
 0.878
ECA0294
Similar to Yersinia pestis putative sodium/calcium exchanger protein ypo3576 SWALL:Q8ZB49 (EMBL:AJ414157) (324 aa) fasta scores: E(): 1.8e-83, 71.69% id in 318 aa, and to Escherichia coli hypothetical protein YrbG SWALL:YRBG_ECOLI (SWALL:P45394) (325 aa) fasta scores: E(): 3.3e-71, 59.81% id in 321 aa.
  
  
 0.789
rpoN
RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.708
kdtA
3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
  
 0.673
lpxK
Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
 
   
 0.666
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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