STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sspBStringent starvation protein B; Similar to Escherichia coli, and Escherichia coli O157:H7 stringent starvation protein B SspB or b3228 or z4586 or ecs4101 SWALL:SSPB_ECOLI (SWALL:P25663) (165 aa) fasta scores: E(): 3e-39, 71.42% id in 168 aa. (167 aa)    
Predicted Functional Partners:
sspA
Stringent starvation protein A; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri stringent starvation protein A SspA or Ssp or Pog or b3229 or c3982 or z4587 or ecs4102 or sf3269 SWALL:SSPA_ECOLI (SWALL:P05838) (211 aa) fasta scores: E(): 6.2e-67, 84.61% id in 208 aa; Belongs to the GST superfamily.
 
  
 0.995
clpX
ATP-dependent Clp protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
    
 
 0.938
clpP
ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
    
 
 0.897
rseA
sigma-E factor negative regulator; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...]
    
 
 0.865
smpA
Putative outer membrane lipopotein (small protein A); Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
    0.774
ftsB
Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
  
     0.756
clpS
Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.
      
 0.745
holA
Similar to Escherichia coli DNA polymerase III, delta subunit HolA or b0640 SWALL:HOLA_ECOLI (SWALL:P28630) (343 aa) fasta scores: E(): 6.2e-94, 69.79% id in 341 aa.
  
     0.715
ECA3218
Similar to Yersinia pestis putative membrane protein ypo2877 or y1355 SWALL:Q8ZCT7 (EMBL:AJ414154) (211 aa) fasta scores: E(): 3.2e-42, 61.13% id in 211 aa, and to Escherichia coli O6 hypothetical protein yfgm or c3035 SWALL:AAN81485 (EMBL:AE016764) (206 aa) fasta scores: E(): 1.8e-40, 57.56% id in 205 aa.
  
    0.709
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.707
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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