STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECA0380Putative endoribonuclease; Similar to Salmonella typhimurium, and Salmonella typhi YjgF SWALL:Q9X445 (EMBL:AF095578) (128 aa) fasta scores: E(): 1.5e-36, 82.81% id in 128 aa, and to Yersinia pestis hypothetical protein Ypo3590 SWALL:Q8ZB37 (EMBL:AJ414157) (128 aa) fasta scores: E(): 5.4e-37, 83.59% id in 128 aa. (128 aa)    
Predicted Functional Partners:
fusA
Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
   
 0.714
pyrI
Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase.
  
    0.680
pyrB
Aspartate carbamoyltransferase catalytic subunit; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri aspartate carbamoyltransferase catalytic chain PyrB or b4245 or c5345 or z5856 or ecs5222 or sf4245 SWALL:PYRB_ECOLI (SWALL:P00479) (310 aa) fasta scores: E(): 7.7e-100, 85.43% id in 309 aa; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
    0.648
tdcB
Putative threonine dehydratase catabolic; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri threonine dehydratase catabolic TdcB or b3117 or c3875 or z4469 or ecs3997 or sf3157 SWALL:THD2_ECOLI (SWALL:P05792) (329 aa) fasta scores: E(): 9.6e-33, 38.14% id in 312 aa, and to Thermotoga maritima threonine dehydratase catabolic tm0356 SWALL:Q9WYJ1 (EMBL:AE001716) (401 aa) fasta scores: E(): 6.1e-41, 41.32% id in 317 aa.
 
 
 0.626
ECA2040
Catabolic threonine dehydratase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri threonine dehydratase catabolic TdcB or b3117 or c3875 or z4469 or ecs3997 or sf3157 SWALL:THD2_ECOLI (SWALL:P05792) (329 aa) fasta scores: E(): 1.8e-38, 39.44% id in 322 aa, and to Pseudomonas aeruginosa probable serine/threonine dehydratase, degradative pa2683 SWALL:Q9I0F5 (EMBL:AE004696) (320 aa) fasta scores: E(): 4.2e-90, 74.13% id in 317 aa.
 
 
 0.518
rph
Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
  
 
 0.502
nnrE
Putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of [...]
  
  
 0.478
ECA2376
Putative endoribonuclease; Similar to Escherichia coli, Escherichia coli O6, and Shigella flexneri hypothetical protein yoab or b1809 or c2213 or sf1419 SWALL:YOAB_ECOLI (SWALL:P76258) (114 aa) fasta scores: E(): 6.4e-31, 73.68% id in 114 aa, and to Yersinia pestis hypothetical protein ypo2070 or y2240 SWALL:Q8ZET3 (EMBL:AJ414151) (114 aa) fasta scores: E(): 1.4e-30, 71.93% id in 114 aa.
 
   
 0.477
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
 
 
 0.458
ECA0379
Similar to Pseudomonas aeruginosa hypothetical protein pa1730 SWALL:Q9I307 (EMBL:AE004599) (470 aa) fasta scores: E(): 9.3e-133, 68.88% id in 466 aa. Note that there are no significant database matches to enterobacterial species.
       0.445
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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