STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadRSimilar to Salmonella typhimurium transcriptional regulator NadR SWALL:NADR_SALTY (SWALL:P24518) (410 aa) fasta scores: E(): 1.1e-140, 85.5% id in 407 aa, and to Escherichia coli transcriptional regulator NadR or NadI or b4390 SWALL:NADR_ECOLI (SWALL:P27278) (410 aa) fasta scores: E(): 2.2e-139, 83.9% id in 410 aa. (417 aa)    
Predicted Functional Partners:
cobB
Putative cobalamin biosynthesis/propionate catabolism protein; Similar to Salmonella typhimurium, and Salmonella typhi CobB protein CobB or stm1221 or sty1261 SWALL:COBB_SALTY (SWALL:P97013) (273 aa) fasta scores: E(): 1.4e-80, 74.81% id in 270 aa, and to Escherichia coli CobB protein CobB or b1120 SWALL:COBB_ECOLI (SWALL:P75960) (279 aa) fasta scores: E(): 3.9e-80, 74.44% id in 270 aa; Belongs to the sirtuin family. Class III subfamily.
  
 
 0.992
ECA4381
Putative DNA-binding protein; Similar to Shigella flexneri yjjm gene product yjjm or sf4388 SWALL:AAN45804 (EMBL:AE015445) (304 aa) fasta scores: E(): 2.8e-109, 88.81% id in 304 aa, and to Escherichia coli hypothetical protein yjjm or b4357 SWALL:YJJM_ECOLI (SWALL:P39399) (268 aa) fasta scores: E(): 6.2e-95, 88.06% id in 268 aa.
 
  
 0.957
pncB
Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family.
    
 0.950
nadE
NH3-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.949
ppnK
Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.947
ECA3370
Similar to Yersinia pestis putative competence-damaged protein ypo3308 SWALL:Q8ZBT7 (EMBL:AJ414156) (162 aa) fasta scores: E(): 4.4e-38, 65.43% id in 162 aa, and to Salmonella typhi hypothetical protein Sty2951 SWALL:Q8Z4D3 (EMBL:AL627276) (165 aa) fasta scores: E(): 3.6e-37, 63.8% id in 163 aa; Belongs to the CinA family.
    
 0.946
nadC
Similar to Escherichia coli nicotinate-nucleotide pyrophosphorylase [carboxylating] NadC or b0109 SWALL:NADC_ECOLI (SWALL:P30011) (296 aa) fasta scores: E(): 8.2e-73, 68.94% id in 293 aa; Belongs to the NadC/ModD family.
    
 0.939
nadD
Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
     
 0.938
ECA3925
Similar to Salmonella typhi hypothetical protein Sty3249 SWALL:Q8Z3V2 (EMBL:AL627277) (187 aa) fasta scores: E(): 8.8e-53, 71.65% id in 187 aa, and to Escherichia coli, Escherichia coli O6, and Shigella flexneri protein yqge or b2948 or c3534 or sf2939 SWALL:YQGE_ECOLI (SWALL:P52049) (187 aa) fasta scores: E(): 1.6e-52, 69.51% id in 187 aa; Belongs to the UPF0301 (AlgH) family.
   
    0.921
deoD
Purine nucleoside phosphorylase; Similar to Escherichia coli, and Escherichia coli O157:H7 purine nucleoside phosphorylase deoD or Pup or b4384 or z5986 or ecs5343 SWALL:DEOD_ECOLI (SWALL:P09743) (238 aa) fasta scores: E(): 2.1e-80, 89.07% id in 238 aa.
    
 0.913
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.