STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
serBPhosphoserine phosphatase; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri phosphoserine phosphatase SerB or b4388 or z5989 or ecs5346 or sf4420 SWALL:SERB_ECOLI (SWALL:P06862) (322 aa) fasta scores: E(): 5.7e-81, 71.87% id in 320 aa. (325 aa)    
Predicted Functional Partners:
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 
 0.990
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.979
glyA2
Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.979
cysE
Serine acetyltransferase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri serine acetyltransferase CysEor b3607 or c4429 or z5034 or ecs4485 or sf3646 SWALL:CYSE_ECOLI (SWALL:P05796) (273 aa) fasta scores: E(): 5.1e-90, 86.08% id in 273 aa, and to Yersinia pestis serine acetyltransferase CysE SWALL:Q8ZJM4 (EMBL:AJ414141) (273 aa) fasta scores: E(): 1.5e-92, 89.37% id in 273 aa.
    
 0.974
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 
 0.954
hisI
Similar to Escherichia coli histidine biosynthesis bifunctional protein HisIE [includes: phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase HisI or hisie or b2026 SWALL:HIS2_ECOLI (SWALL:P06989) (203 aa) fasta scores: E(): 2e-64, 80.09% id in 201 aa; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.951
sdaA
L-serine dehydratase 1; Similar to Escherichia coli L-serine dehydratase 1 SdaA or b1814 SWALL:SDHL_ECOLI (SWALL:P16095) (454 aa) fasta scores: E(): 5.1e-154, 83.92% id in 454 aa. Also similar to ECA3159 (SdaB) (75.165% id. in 455 aa overlap); Belongs to the iron-sulfur dependent L-serine dehydratase family.
   
 
 0.949
sdaB
L-serine dehydratase 2; Similar to Escherichia coli L-serine dehydratase 2 SdaB or b2797 SWALL:SDHM_ECOLI (SWALL:P30744) (455 aa) fasta scores: E(): 2.1e-132, 71.2% id in 455 aa. Also similar to ECA2380 (SdaA) (75.165% id. in 455 aa overlap); Belongs to the iron-sulfur dependent L-serine dehydratase family.
   
 
 0.949
ECA0389
Putative hydrolase; Similar to Bradyrhizobium japonicum protein blr6677 SWALL:BAC51942 (EMBL:AP005959) (353 aa) fasta scores: E(): 9.7e-77, 55.45% id in 339 aa, and to Caulobacter crescentus hydrolase, alpha/beta hydrolase fold family cc3204 SWALL:Q9A3K0 (EMBL:AE005984) (358 aa) fasta scores: E(): 1.5e-48, 44.41% id in 331 aa. Note that there are no significant database matches to enterobacterial species.
   
 
 0.946
metA
Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family.
     
 0.946
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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