| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ECA0653 | rlmG | ECA0653 | ECA0654 | Putative oxidoreductase; Similar to Escherichia coli O6 hypothetical oxidoreductase YgjR SWALL:AAN82290 (EMBL:AE016767) (334 aa) fasta scores: E(): 2.7e-91, 70.76% id in 325 aa. | Conserved hypothetical protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 0.576 |
| hepA | rlmG | ECA3853 | ECA0654 | RNA polymerase associated protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | Conserved hypothetical protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 0.478 |
| hepA | rpoB | ECA3853 | ECA0223 | RNA polymerase associated protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | DNA-directed RNA polymerase, beta-subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.871 |
| nusA | rlmG | ECA0711 | ECA0654 | N utilization substance protein A; Participates in both transcription termination and antitermination. | Conserved hypothetical protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 0.432 |
| nusA | rplA | ECA0711 | ECA0220 | N utilization substance protein A; Participates in both transcription termination and antitermination. | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.956 |
| nusA | rplL | ECA0711 | ECA0222 | N utilization substance protein A; Participates in both transcription termination and antitermination. | 50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. | 0.856 |
| nusA | rpoB | ECA0711 | ECA0223 | N utilization substance protein A; Participates in both transcription termination and antitermination. | DNA-directed RNA polymerase, beta-subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.996 |
| nusA | rpsG | ECA0711 | ECA4037 | N utilization substance protein A; Participates in both transcription termination and antitermination. | 30S ribosomal subunit protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. | 0.957 |
| nusA | uppS | ECA0711 | ECA1036 | N utilization substance protein A; Participates in both transcription termination and antitermination. | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.680 |
| obg | rlmG | ECA0693 | ECA0654 | Putative GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | Conserved hypothetical protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 0.546 |
| obg | rplA | ECA0693 | ECA0220 | Putative GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.938 |
| obg | rplL | ECA0693 | ECA0222 | Putative GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. | 0.496 |
| obg | rpsG | ECA0693 | ECA4037 | Putative GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 30S ribosomal subunit protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. | 0.525 |
| obg | uppS | ECA0693 | ECA1036 | Putative GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.482 |
| rlmG | ECA0653 | ECA0654 | ECA0653 | Conserved hypothetical protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | Putative oxidoreductase; Similar to Escherichia coli O6 hypothetical oxidoreductase YgjR SWALL:AAN82290 (EMBL:AE016767) (334 aa) fasta scores: E(): 2.7e-91, 70.76% id in 325 aa. | 0.576 |
| rlmG | hepA | ECA0654 | ECA3853 | Conserved hypothetical protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | RNA polymerase associated protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.478 |
| rlmG | nusA | ECA0654 | ECA0711 | Conserved hypothetical protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | N utilization substance protein A; Participates in both transcription termination and antitermination. | 0.432 |
| rlmG | obg | ECA0654 | ECA0693 | Conserved hypothetical protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | Putative GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.546 |
| rlmG | rplA | ECA0654 | ECA0220 | Conserved hypothetical protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.447 |
| rlmG | rplL | ECA0654 | ECA0222 | Conserved hypothetical protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. | 50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. | 0.422 |