Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mugG/U mismatch-specific DNA glycosylase; Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells; Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family. (167 aa)    
Predicted Functional Partners:
ECA2211
Copper-zinc superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.
  
   
 0.557
ECA0443
Conserved hypothetical protein; Similar to Escherichia coli, and Shigella flexneri hypothetical protein YoeB SWALL:YOEB_ECOLI (SWALL:P56605) (84 aa) fasta scores: E(): 8.2e-31, 85.71% id in 84 aa.
     
 0.512
ibpA
Heat shock protein A; Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
     
 0.509
ibpB
Heat shock protein B; Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
     
 0.508
cspD
Cold shock-like protein; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri cold shock-like protein CspD or CspH or b0880 or c1017 or z1117 or ecs0966 or sf0840 SWALL:CSPD_ECOLI (SWALL:P24245) (74 aa) fasta scores: E(): 9.7e-25, 87.32% id in 71 aa.
     
 0.504
ECA1566
Putative membrane protein; Similar to Ralstonia solanacearum probable transmembrane protein rsc0603 or rs04842 SWALL:Q8Y1T6 (EMBL:AL646060) (292 aa) fasta scores: E(): 4.1e-18, 32.27% id in 189 aa, and to Escherichia coli, Escherichia coli O6, and Shigella flexneri paraquat-inducible protein a pqia or pqi5a or b0950 or c1086 or sf0951 SWALL:PQIA_ECOLI (SWALL:P43670) (417 aa) fasta scores: E(): 3.4e-07, 23.4% id in 188 aa.
      
 0.500
ECA3410
Similar to Yersinia pestis hypothetical protein ypo3611 or y0263 SWALL:Q8ZB18 (EMBL:AJ414158) (63 aa) fasta scores: E(): 2e-05, 54.54% id in 44 aa.
      
 0.499
frdA
Similar to Escherichia coli fumarate reductase flavoprotein subunit FrdA or b4154 SWALL:FRDA_ECOLI (SWALL:P00363) (601 aa) fasta scores: E(): 4.9e-203, 84.52% id in 601 aa.
      
 0.498
ecnB
Entericidin B; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri entericidin B precursor EcnB or b4147.2 or c5235 or z5754 or ecs5128.2 or sf4305 SWALL:ECNB_ECOLI (SWALL:P56549) (48 aa) fasta scores: E(): 2.8e-06, 61.53% id in 39 aa.
      
 0.497
dps
DNA protection during starvation protein; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
      
 0.496
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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