| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ECA1196 | hflB | ECA1196 | ECA0698 | Putative membrane protein; Similar to Yersinia pestis hypothetical protein ypo3083 or y1096 SWALL:Q8ZCB0 (EMBL:AJ414155) (304 aa) fasta scores: E(): 3.7e-94, 90.13% id in 304 aa, and to Salmonella typhimurium putative inner membrane protein ybbk or stm0501 SWALL:Q8ZR94 (EMBL:AE008719) (305 aa) fasta scores: E(): 2.8e-90, 86.09% id in 302 aa. | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.846 |
| ECA1196 | hflK | ECA1196 | ECA3932 | Putative membrane protein; Similar to Yersinia pestis hypothetical protein ypo3083 or y1096 SWALL:Q8ZCB0 (EMBL:AJ414155) (304 aa) fasta scores: E(): 3.7e-94, 90.13% id in 304 aa, and to Salmonella typhimurium putative inner membrane protein ybbk or stm0501 SWALL:Q8ZR94 (EMBL:AE008719) (305 aa) fasta scores: E(): 2.8e-90, 86.09% id in 302 aa. | Putative phage-related protein; HflC and HflK could encode or regulate a protease. | 0.418 |
| hflB | ECA1196 | ECA0698 | ECA1196 | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Putative membrane protein; Similar to Yersinia pestis hypothetical protein ypo3083 or y1096 SWALL:Q8ZCB0 (EMBL:AJ414155) (304 aa) fasta scores: E(): 3.7e-94, 90.13% id in 304 aa, and to Salmonella typhimurium putative inner membrane protein ybbk or stm0501 SWALL:Q8ZR94 (EMBL:AE008719) (305 aa) fasta scores: E(): 2.8e-90, 86.09% id in 302 aa. | 0.846 |
| hflB | hflC | ECA0698 | ECA3931 | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Putative phage-related protein; HflC and HflK could regulate a protease. | 0.890 |
| hflB | hflK | ECA0698 | ECA3932 | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Putative phage-related protein; HflC and HflK could encode or regulate a protease. | 0.930 |
| hflB | rplB | ECA0698 | ECA4028 | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 0.811 |
| hflB | rplM | ECA0698 | ECA0306 | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.800 |
| hflB | rpsE | ECA0698 | ECA4014 | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 30S ribosomal subunit protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. | 0.811 |
| hflB | rpsK | ECA0698 | ECA4008 | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 30S ribosomal subunit protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. | 0.805 |
| hflB | rrmJ | ECA0698 | ECA0697 | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Ribosomal RNA large subunit methyltransferase; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | 0.893 |
| hflB | secA | ECA0698 | ECA3806 | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.832 |
| hflB | secY | ECA0698 | ECA4011 | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Preprotein translocase subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.816 |
| hflC | hflB | ECA3931 | ECA0698 | Putative phage-related protein; HflC and HflK could regulate a protease. | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.890 |
| hflC | hflK | ECA3931 | ECA3932 | Putative phage-related protein; HflC and HflK could regulate a protease. | Putative phage-related protein; HflC and HflK could encode or regulate a protease. | 0.988 |
| hflK | ECA1196 | ECA3932 | ECA1196 | Putative phage-related protein; HflC and HflK could encode or regulate a protease. | Putative membrane protein; Similar to Yersinia pestis hypothetical protein ypo3083 or y1096 SWALL:Q8ZCB0 (EMBL:AJ414155) (304 aa) fasta scores: E(): 3.7e-94, 90.13% id in 304 aa, and to Salmonella typhimurium putative inner membrane protein ybbk or stm0501 SWALL:Q8ZR94 (EMBL:AE008719) (305 aa) fasta scores: E(): 2.8e-90, 86.09% id in 302 aa. | 0.418 |
| hflK | hflB | ECA3932 | ECA0698 | Putative phage-related protein; HflC and HflK could encode or regulate a protease. | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.930 |
| hflK | hflC | ECA3932 | ECA3931 | Putative phage-related protein; HflC and HflK could encode or regulate a protease. | Putative phage-related protein; HflC and HflK could regulate a protease. | 0.988 |
| hflK | secY | ECA3932 | ECA4011 | Putative phage-related protein; HflC and HflK could encode or regulate a protease. | Preprotein translocase subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.412 |
| rplB | hflB | ECA4028 | ECA0698 | 50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.811 |
| rplB | rplM | ECA4028 | ECA0306 | 50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.997 |