STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-expression
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[Homology]
Score
dhpSDihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (277 aa)    
Predicted Functional Partners:
folC
Bifunctional protein [includes: folylpolyglutamate synthase and dihydrofolate synthase]; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.
 
 0.999
folK
Similar to Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK or b0142 SWALL:HPPK_ECOLI (SWALL:P26281) (158 aa) fasta scores: E(): 1.5e-39, 67.08% id in 158 aa.
 
 0.999
folB
Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
 
 0.995
folE
GTP cyclohydrolase I; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri GTP cyclohydrolase I FolE or b2153 or c2688 or z3409 or ecs3045 or sf2238 SWALL:GCH1_ECOLI (SWALL:P27511) (221 aa) fasta scores: E(): 9.1e-71, 88.18% id in 220 aa.
 
 
 0.982
pabC
Similar to Escherichia coli 4-amino-4-deoxychorismate lyase PabC or b1096 SWALL:PABC_ECOLI (SWALL:P28305) (269 aa) fasta scores: E(): 7.2e-51, 53.96% id in 265 aa.
  
 
 0.981
mrsA
Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.
  
  
 0.935
folX
D-erythro-7,8-dihydroneopterin triphosphate epimerase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri D-erythro-7,8-dihydroneopterin triphosphate epimerase FolX or b2303 or c2846 or z3565 or ecs3187 or sf2379 SWALL:FOLX_ECOLI (SWALL:P80449) (119 aa) fasta scores: E(): 1.1e-32, 77.39% id in 115 aa.
  
 
 0.837
ehpC
Putative phenazine antibiotic biosynthesis protein; Similar to Pseudomonas aeruginosa PhzE and pa4214 SWALL:O33410 (EMBL:AF005404) (627 aa) fasta scores: E(): 1.2e-105, 45.65% id in 622 aa, and to Pantoea agglomerans EhpC SWALL:AAN40892 (EMBL:AF451953) (634 aa) fasta scores: E(): 6.8e-55, 37.82% id in 624 aa.
 
 
 0.833
ribD
Riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
 
   
 0.736
hflB
Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
  
 0.733
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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