STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uxuBSimilar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 4.5e-107, 56.03% id in 489 aa, and to Yersinia pestis putative D-mannonate oxidoreductase ypo1280 or y2903 SWALL:AAM86454 (EMBL:AJ414147) (490 aa) fasta scores: E(): 8.7e-128, 63.93% id in 488 aa. Also similar to ECA0920 (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family. (491 aa)    
Predicted Functional Partners:
uxuA
Mannonate dehydratase; Catalyzes the dehydration of D-mannonate; Belongs to the mannonate dehydratase family.
 
 
 0.966
uxaC
Uronate isomerase; Similar to Escherichia coli, Escherichia coli O6, and Shigella flexneri uronate isomerase UxaC or b3092 or c3850 or sf3132 SWALL:UXAC_ECOLI (SWALL:P42607) (470 aa) fasta scores: E(): 8.6e-183, 89.33% id in 469 aa.
 
 
 0.956
mtlA
Similar to Escherichia coli PTS system, mannitol-specific IIabc component MtlA or b3599 SWALL:PTMA_ECOLI (SWALL:P00550) (637 aa) fasta scores: E(): 1.1e-188, 81.63% id in 637 aa.
  
  
 0.955
rspA
Putative starvation sensing mandelate racemase / muconate lactonizing enzyme; Similar to Escherichia coli starvation sensing protein RspA SWALL:RSPA_ECOLI (SWALL:P38104) (404 aa) fasta scores: E(): 5.7e-163, 92.57% id in 404 aa. Also similar to ECA0189 (36.070% id. in 402 aa overlap).
 
  
 0.923
rspB
Putative starvation sensing zinc-binding dehydrogenase; Similar to Escherichia coli starvation sensing protein RspB or b1580 SWALL:RSPB_ECOLI (SWALL:P38105) (339 aa) fasta scores: E(): 5.6e-94, 73.45% id in 339 aa.
    
 0.905
ECA0189
Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
    
 0.904
ECA0920
Probable carbohydrate oxidoreductase; Similar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 1.5e-102, 54.83% id in 476 aa, and to Escherichia coli hypothetical oxidoreductase ydfi or b1542 SWALL:YDFI_ECOLI (SWALL:P77260) (486 aa) fasta scores: E(): 1.2e-127, 65.26% id in 475 aa. Also similar to ECA0819 (UxuB) (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family.
  
  
 
0.903
uxaA
Similar to Escherichia coli altronate hydrolase UxaA SWALL:UXAA_ECOLI (SWALL:P42604) (495 aa) fasta scores: E(): 4.1e-163, 80.24% id in 496 aa.
 
  
 0.674
fruB
Similar to Escherichia coli, and Escherichia coli O157:H7 PTS system, fructose-specific IIa/Fpr component FruB or FruF or Fpr or b2169 or z3427 or ecs3061 SWALL:PTFA_ECOLI (SWALL:P24217) (376 aa) fasta scores: E(): 5.9e-97, 69.41% id in 376 aa.
  
  
 0.649
ECA0921
GntR-family transcriptional regulator; Similar to Escherichia coli, and Escherichia coli O157:H7 hypothetical transcriptional regulator YdfH SWALL:YDFH_ECOLI (SWALL:P77577) (228 aa) fasta scores: E(): 2e-51, 60.88% id in 225 aa, and to Salmonella typhimurium, and Salmonella typhi putative regulatory protein, GntR-family stm1510 or sty1551 SWALL:Q8XFZ6 (EMBL:AE008766) (228 aa) fasta scores: E(): 2.3e-50, 60% id in 225 aa.
   
 0.471
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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