STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uxuBSimilar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 4.5e-107, 56.03% id in 489 aa, and to Yersinia pestis putative D-mannonate oxidoreductase ypo1280 or y2903 SWALL:AAM86454 (EMBL:AJ414147) (490 aa) fasta scores: E(): 8.7e-128, 63.93% id in 488 aa. Also similar to ECA0920 (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family. (491 aa)    
Predicted Functional Partners:
uxuA
Mannonate dehydratase; Catalyzes the dehydration of D-mannonate; Belongs to the mannonate dehydratase family.
 
 
 0.988
uxaC
Uronate isomerase; Similar to Escherichia coli, Escherichia coli O6, and Shigella flexneri uronate isomerase UxaC or b3092 or c3850 or sf3132 SWALL:UXAC_ECOLI (SWALL:P42607) (470 aa) fasta scores: E(): 8.6e-183, 89.33% id in 469 aa.
 
 
 0.987
mtlA
Similar to Escherichia coli PTS system, mannitol-specific IIabc component MtlA or b3599 SWALL:PTMA_ECOLI (SWALL:P00550) (637 aa) fasta scores: E(): 1.1e-188, 81.63% id in 637 aa.
  
 
 0.966
rspA
Putative starvation sensing mandelate racemase / muconate lactonizing enzyme; Similar to Escherichia coli starvation sensing protein RspA SWALL:RSPA_ECOLI (SWALL:P38104) (404 aa) fasta scores: E(): 5.7e-163, 92.57% id in 404 aa. Also similar to ECA0189 (36.070% id. in 402 aa overlap).
 
  
 0.957
ECA0189
Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
    
 0.947
rspB
Putative starvation sensing zinc-binding dehydrogenase; Similar to Escherichia coli starvation sensing protein RspB or b1580 SWALL:RSPB_ECOLI (SWALL:P38105) (339 aa) fasta scores: E(): 5.6e-94, 73.45% id in 339 aa.
    
 0.947
ECA0920
Probable carbohydrate oxidoreductase; Similar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 1.5e-102, 54.83% id in 476 aa, and to Escherichia coli hypothetical oxidoreductase ydfi or b1542 SWALL:YDFI_ECOLI (SWALL:P77260) (486 aa) fasta scores: E(): 1.2e-127, 65.26% id in 475 aa. Also similar to ECA0819 (UxuB) (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family.
     
  0.944
fruA
Similar to Escherichia coli pts system, fructose-specific IIbc component FruA or PtsF or b2167 SWALL:PTFB_ECOLI (SWALL:P20966) (563 aa) fasta scores: E(): 1.4e-146, 75.13% id in 567 aa.
  
 
 0.818
fruB
Similar to Escherichia coli, and Escherichia coli O157:H7 PTS system, fructose-specific IIa/Fpr component FruB or FruF or Fpr or b2169 or z3427 or ecs3061 SWALL:PTFA_ECOLI (SWALL:P24217) (376 aa) fasta scores: E(): 5.9e-97, 69.41% id in 376 aa.
  
 
 0.753
uxaA
Similar to Escherichia coli altronate hydrolase UxaA SWALL:UXAA_ECOLI (SWALL:P42604) (495 aa) fasta scores: E(): 4.1e-163, 80.24% id in 496 aa.
 
 
 0.724
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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