STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemFCoproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (310 aa)    
Predicted Functional Partners:
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.992
hemG
Protoporphyrinogen oxidase; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 protoporphyrinogen oxidase HemG or b3850 or c4797 or z5372 or ecs4778 SWALL:HEMG_ECOLI (SWALL:P27863) (181 aa) fasta scores: E(): 8.5e-44, 62.14% id in 177 aa.
     
 0.983
hemN
Similar to Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN SWALL:HEMN_ECOLI (SWALL:P32131) (457 aa) fasta scores: E(): 3.5e-152, 80.96% id in 457 aa; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
    
 0.962
ECA0873
Similar to Yersinia pestis hypothetical protein ypo3033 SWALL:YU33_YERPE (SWALL:Q8ZCF8) (152 aa) fasta scores: E(): 1.4e-47, 88.51% id in 148 aa, and to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 hypothetical protein YaiI SWALL:YAII_ECOLI (SWALL:P52088) (152 aa) fasta scores: E(): 1.2e-42, 78% id in 150 aa; Belongs to the UPF0178 family.
       0.807
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.750
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 
 0.705
hemY
Porphyrin biosynthetic protein; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri HemY protein HemY or b3802 or c4721 or z5316 or ecs4732 or sf3874 SWALL:HEMY_ECOLI (SWALL:P09128) (398 aa) fasta scores: E(): 1.3e-109, 73.02% id in 393 aa, and to Salmonella typhi porphyrin biosynthetic protein sty3624 SWALL:Q8Z398 (EMBL:AL627279) (399 aa) fasta scores: E(): 7e-108, 71.24% id in 393 aa.
    
 0.698
hemB
Similar to Pseudomonas aeruginosa delta-aminolevulinic acid dehydratase HemB or PA5243 SWALL:HEM2_PSEAE (SWALL:Q59643) (337 aa) fasta scores: E(): 5.1e-86, 71.69% id in 325 aa, and to Yersinia pestis delta-aminolevulinic acid dehydratase HemB SWALL:Q8ZAM5 (EMBL:AJ414158) (340 aa) fasta scores: E(): 6.8e-115, 90.29% id in 340 aa; Belongs to the ALAD family.
 
 
 0.675
trmL
Putative RNA-methyltransferase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.
      0.627
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
     
 0.564
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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