STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
macBMacrolide-specific ABC-type efflux carrier; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (650 aa)    
Predicted Functional Partners:
macA
Similar to Escherichia coli macrolide-specific efflux protein MacA precursor MacA or b0878 SWALL:MACA_ECOLI (SWALL:P75830) (371 aa) fasta scores: E(): 8.9e-30, 37.17% id in 390 aa, and to Yersinia pestis putative HlyD family secretion protein ypo2999 or y1481 SWALL:AAM85052 (EMBL:AJ414154) (401 aa) fasta scores: E(): 3.8e-78, 64.69% id in 405 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.993
acrA
Acriflavine resistance protein A; Similar to Escherichia coli, and Escherichia coli O157:H7 acriflavine resistance protein a precursor AcrA or MtcA or Lir or b0463 or z0578 or ecs0516 SWALL:ACRA_ECOLI (SWALL:P31223) (397 aa) fasta scores: E(): 4e-103, 72.29% id in 397 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.920
mexC
Multidrug resistance protein; Similar to Pseudomonas aeruginosa membrane fusion protein MexC or pa4599 SWALL:Q51395 (EMBL:U57969) (387 aa) fasta scores: E(): 6.2e-63, 50.78% id in 384 aa, and to uncultured bacterium MexC protein MexC SWALL:Q8RSM2 (EMBL:AJ431260) (388 aa) fasta scores: E(): 9.2e-63, 53.6% id in 375 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.914
cusB
Similar to Escherichia coli putative copper efflux system protein CusB precursor CusB or b0574 SWALL:CUSB_ECOLI (SWALL:P77239) (407 aa) fasta scores: E(): 8.2e-44, 37.94% id in 398 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.893
ECA1386
Putative exported protein; Similar to Escherichia coli hypothetical protein CusX precursor CusX or b0573 SWALL:CUSX_ECOLI (SWALL:P77214) (110 aa) fasta scores: E(): 1.5e-06, 35.13% id in 111 aa, and to Shigella flexneri orf, conserved hypothetical protein ylcc or sf0474 SWALL:AAN42127 (EMBL:AE015079) (110 aa) fasta scores: E(): 1.5e-06, 35.13% id in 111 aa.
  
 
 0.893
ECA0801
Putative exported protein; Similar to Vibrio cholerae hypothetical protein vc0913 SWALL:Q9KTI9 (EMBL:AE004175) (352 aa) fasta scores: E(): 2.3e-10, 26.29% id in 232 aa, and to Shewanella oneidensis HlyD family secretion protein so3483 SWALL:AAN56476 (EMBL:AE015784) (369 aa) fasta scores: E(): 2.4e-09, 25.49% id in 251 aa. Note that there are no significant database matches to enterobacterial species; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.889
ECA0802
Putative membrane protein; Similar to Vibrio cholerae hypothetical protein vc0913 SWALL:Q9KTI9 (EMBL:AE004175) (352 aa) fasta scores: E(): 1.9e-05, 24.12% id in 228 aa, and to Vibrio cholerae periplasmic linker protein, putative vc1756 SWALL:Q9KR86 (EMBL:AE004253) (364 aa) fasta scores: E(): 4e-05, 27.53% id in 247 aa.
  
 
 0.889
ECA0803
Putative membrane protein; No significant database matches.
  
 
 0.889
ECA2930
HlyD-family secretion protein; Similar to Pseudomonas putida RND efflux membrane fusion protein pp3301 SWALL:AAN68908 (EMBL:AE016786) (367 aa) fasta scores: E(): 2.8e-81, 70.1% id in 368 aa, and to Xylella fastidiosa component of multidrug efflux system xf2084 SWALL:Q9PBQ6 (EMBL:AE004023) (368 aa) fasta scores: E(): 3.9e-75, 63.95% id in 369 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.889
mdtA
Similar to Salmonella typhimurium putative HlyD family secretion protein stm2126 SWALL:Q8ZNQ3 (EMBL:AE008794) (413 aa) fasta scores: E(): 1.9e-84, 63.27% id in 403 aa, and to Salmonella typhi putative efflux system protein sty2339 SWALL:Q8Z5F8 (EMBL:AL627273) (413 aa) fasta scores: E(): 2.2e-84, 63.27% id in 403 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.889
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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