STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
macASimilar to Escherichia coli macrolide-specific efflux protein MacA precursor MacA or b0878 SWALL:MACA_ECOLI (SWALL:P75830) (371 aa) fasta scores: E(): 8.9e-30, 37.17% id in 390 aa, and to Yersinia pestis putative HlyD family secretion protein ypo2999 or y1481 SWALL:AAM85052 (EMBL:AJ414154) (401 aa) fasta scores: E(): 3.8e-78, 64.69% id in 405 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (398 aa)    
Predicted Functional Partners:
macB
Macrolide-specific ABC-type efflux carrier; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
 
 
 0.993
acrD
Similar to Escherichia coli probable aminoglycoside efflux pump AcrD or b2470 SWALL:ACRD_ECOLI (SWALL:P24177) (1037 aa) fasta scores: E(): 0, 79.51% id in 1035 aa, and to Escherichia coli acriflavine resistance protein B AcrB or AcrE or b0462 SWALL:ACRB_ECOLI (SWALL:P31224) (1049 aa) fasta scores: E(): 0, 64.87% id in 1042 aa.
 
 
 0.746
mexB
Similar to Pseudomonas aeruginosa multidrug resistance protein MexB or pa0426 SWALL:MEXB_PSEAE (SWALL:P52002) (1046 aa) fasta scores: E(): 1.9e-202, 50.82% id in 1037 aa, and to uncultured bacterium MexD protein mexD SWALL:Q8RSM1 (EMBL:AJ431260) (1047 aa) fasta scores: E(): 0, 64.14% id in 1043 aa.
 
 
 0.740
acrB
Similar to Escherichia coli acriflavine resistance protein B AcrB or AcrE or b0462 SWALL:ACRB_ECOLI (SWALL:P31224) (1049 aa) fasta scores: E(): 0, 80.84% id in 1039 aa.
 
 
 0.736
mdtC
Similar to Escherichia coli multidrug transporter MdtC SWALL:BAC06609 (EMBL:AB089189) (1025 aa) fasta scores: E(): 0, 79.29% id in 1024 aa, and to Yersinia pestis acrb/acrd/acrf family membrane protein ypo2849 or y1384 SWALL:Q8ZCV9 (EMBL:AJ414154) (1024 aa) fasta scores: E(): 0, 79.68% id in 1019 aa; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
 
 
 0.576
ECA2929
Putative efflux protein; Similar to Pseudomonas putida rnd efflux transporter pp3302 SWALL:AAN68909 (EMBL:AE016786) (1030 aa) fasta scores: E(): 0, 84.11% id in 1020 aa, and to Xylella fastidiosa cation efflux system protein xf2083 SWALL:Q9PBQ7 (EMBL:AE004023) (1020 aa) fasta scores: E(): 0, 83.38% id in 1017 aa; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
 
 0.562
oprJ
Similar to Pseudomonas aeruginosa outer membrane protein OprJ precursor OprJ or pa4597 SWALL:OPRJ_PSEAE (SWALL:Q51397) (479 aa) fasta scores: E(): 1.2e-94, 57.82% id in 460 aa, and to Pseudomonas putida TtgC SWALL:Q9WWZ8 (EMBL:AF031417) (484 aa) fasta scores: E(): 2.4e-70, 45.14% id in 474 aa, and to Pseudomonas aeruginosa outer membrane protein oprm precursor oprm or oprk or pa0427 SWALL:OPRM_PSEAE (SWALL:Q51487) (485 aa) fasta scores: E(): 1.9e-66, 46.78% id in 466 aa.
 
 
 0.561
ECA0890
Two-component system sensor kinase; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 sensor protein CpxA or EcfB or Ssd or Eup or b3911 or c4863 or z5456 or ecs4837 SWALL:CPXA_ECOLI (SWALL:P08336) (457 aa) fasta scores: E(): 2.2e-23, 29.53% id in 474 aa, and to Yersinia pestis putative two-component system sensor kinase ypo2997 or y1483 SWALL:Q8ZCJ0 (EMBL:AJ414154) (449 aa) fasta scores: E(): 1e-91, 56.86% id in 459 aa.
 
   
 0.545
mdtB
Similar to Escherichia coli multidrug transporter MdtB SWALL:BAC06608 (EMBL:AB089188) (1040 aa) fasta scores: E(): 0, 78.92% id in 1039 aa, and to Yersinia pestis acrb/acrd/acrf family membrane protein ypo2848 or y1385 SWALL:Q8ZCW0 (EMBL:AJ414154) (1052 aa) fasta scores: E(): 0, 80.73% id in 1038 aa; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
 
 
 0.529
ECA0889
Two-component system response regulator; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri transcriptional regulatory protein CpxR or b3912 or z5457 or ecs4838 or sf3991 SWALL:CPXR_ECOLI (SWALL:P16244) (232 aa) fasta scores: E(): 3.5e-31, 44.93% id in 227 aa, and to Yersinia pestis putative two-component system response regulator ypo2998 or cpxr or y1482 SWALL:Q8ZCI9 (EMBL:AJ414154) (227 aa) fasta scores: E(): 1.3e-67, 77.97% id in 227 aa.
     
 0.466
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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