STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
macASimilar to Escherichia coli macrolide-specific efflux protein MacA precursor MacA or b0878 SWALL:MACA_ECOLI (SWALL:P75830) (371 aa) fasta scores: E(): 8.9e-30, 37.17% id in 390 aa, and to Yersinia pestis putative HlyD family secretion protein ypo2999 or y1481 SWALL:AAM85052 (EMBL:AJ414154) (401 aa) fasta scores: E(): 3.8e-78, 64.69% id in 405 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (398 aa)    
Predicted Functional Partners:
macB
Macrolide-specific ABC-type efflux carrier; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
 
 
 0.991
mexB
Similar to Pseudomonas aeruginosa multidrug resistance protein MexB or pa0426 SWALL:MEXB_PSEAE (SWALL:P52002) (1046 aa) fasta scores: E(): 1.9e-202, 50.82% id in 1037 aa, and to uncultured bacterium MexD protein mexD SWALL:Q8RSM1 (EMBL:AJ431260) (1047 aa) fasta scores: E(): 0, 64.14% id in 1043 aa.
 
 0.803
acrB
Similar to Escherichia coli acriflavine resistance protein B AcrB or AcrE or b0462 SWALL:ACRB_ECOLI (SWALL:P31224) (1049 aa) fasta scores: E(): 0, 80.84% id in 1039 aa.
 
 0.800
acrD
Similar to Escherichia coli probable aminoglycoside efflux pump AcrD or b2470 SWALL:ACRD_ECOLI (SWALL:P24177) (1037 aa) fasta scores: E(): 0, 79.51% id in 1035 aa, and to Escherichia coli acriflavine resistance protein B AcrB or AcrE or b0462 SWALL:ACRB_ECOLI (SWALL:P31224) (1049 aa) fasta scores: E(): 0, 64.87% id in 1042 aa.
 
 0.792
ECA0425
Putative outer membrane efflux protein; Similar to Vibrio cholerae hypothetical protein Vc1606 SWALL:Q9KRN0 (EMBL:AE004238) (476 aa) fasta scores: E(): 6e-69, 44.34% id in 451 aa, and to Shewanella oneidensis outer membrane efflux protein so4090 SWALL:AAN57064 (EMBL:AE015839) (473 aa) fasta scores: E(): 1.2e-68, 45.11% id in 450 aa.
 
 0.768
tolC
Similar to Escherichia coli outer membrane protein TolC precursor TolC or MtcB or MukA or RefI or b3035 SWALL:TOLC_ECOLI (SWALL:P02930) (495 aa) fasta scores: E(): 4.1e-124, 75.32% id in 466 aa, and to Erwinia chrysanthemi outer membrane protein TolC SWALL:Q93AG1 (EMBL:AF421372) (472 aa) fasta scores: E(): 2.3e-128, 77.89% id in 466 aa.
  
 0.738
hasF
Similar to Pseudomonas fluorescens outer membrane protein HasF SWALL:Q9RHT0 (EMBL:AB023289) (442 aa) fasta scores: E(): 1.5e-85, 54.96% id in 433 aa, and to Erwinia chrysanthemi proteases secretion protein PrtF precursor prtF SWALL:PRTF_ERWCH (SWALL:P23598) (462 aa) fasta scores: E(): 2.1e-75, 48.82% id in 424 aa. Also similar to ECA2781 (48.956% identity in 431 aa overlap).
  
 0.738
prtF
Similar to Erwinia chrysanthemi proteases secretion protein PrtF precursor SWALL:PRTF_ERWCH (SWALL:P23598) (462 aa) fasta scores: E(): 3.6e-123, 73.25% id in 445 aa. Also similar to ECA1534 (48.956% in 431 aa overlap.
  
 0.738
ECA1098
Putative type I secretion protein; Similar to Escherichia coli O157:H7 putative outer membrane export protein z0608 or ecs0540 SWALL:Q8XD20 (EMBL:AE005228) (451 aa) fasta scores: E(): 2.7e-75, 50.56% id in 439 aa, and to Ralstonia solanacearum putative outer membrane efflux transmembrane protein rsp1181 or rs06134 SWALL:Q8XQP1 (EMBL:AL646083) (483 aa) fasta scores: E(): 1.9e-23, 29.39% id in 398 aa.
  
 0.689
aggA
Agglutination protein; Similar to Pseudomonas putida agglutination protein precursor AggA SWALL:Q52018 (EMBL:M64540) (452 aa) fasta scores: E(): 4e-73, 47.27% id in 440 aa, and to Vibrio cholerae agglutination protein vc1621 SWALL:Q9KRL6 (EMBL:AE004240) (445 aa) fasta scores: E(): 1.6e-51, 36.58% id in 421 aa.
  
 0.689
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: medium (56%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.