STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
norVAnaerobic nitric oxide reductase flavorubredoxin; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family. (509 aa)    
Predicted Functional Partners:
norW
Nitric oxide reductase FlrD-NAD(+) reductase; One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase.
 
 0.999
nasB
Similar to Klebsiella pneumoniae nitrite reductase [NAD(P)H] large subunit NasB SWALL:NIRB_KLEPN (SWALL:Q06458) (957 aa) fasta scores: E(): 0, 70.89% id in 962 aa; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
 
 0.894
norR
Nitric oxide reductase sigma-54-dependent transcriptional regulator; Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54.
 
   
 0.886
nirB
Similar to Escherichia coli nitrite reductase [NAD(P)H] large subunit NirB or b3365 SWALL:NIRB_ECOLI (SWALL:P08201) (847 aa) fasta scores: E(): 0, 80.45% id in 844 aa; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
 
 0.882
hmpX
Flavohemoprotein; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily.
  
  
 0.803
ftnA
Ferritin; Iron-storage protein.
 
  
 0.770
hcp
Prismane protein homolog (hybrid-cluster protein); Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
 
   
 0.761
nrfA
Cytochrome c552 precursor; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family.
  
   
 0.752
ECA0824
Similar to Rhodospirillum rubrum pyruvate-flavodoxin oxidoreductase NifJ SWALL:NIFJ_RHORU (SWALL:Q53046) (1191 aa) fasta scores: E(): 0, 54.73% id in 1182 aa, and to Escherichia coli probable pyruvate-flavodoxin oxidoreductase ydbk or b1378 SWALL:NIFJ_ECOLI (SWALL:P52647) (1174 aa) fasta scores: E(): 0, 78.79% id in 1174 aa. Also similar to ECA2957 (47.377% id. in 1182 aa overlap).
  
  
 0.721
ECA1474
Conserved hypothetical protein; Similar to Escherichia coli, and Escherichia coli O157:H7 hypothetical protein year or b1797 or z2839 or ecs2506 SWALL:YEAR_ECOLI (SWALL:P76248) (119 aa) fasta scores: E(): 3.1e-30, 66.66% id in 105 aa, and to Salmonella typhi hypothetical protein Sty1850 SWALL:Q8Z6D6 (EMBL:AL627271) (120 aa) fasta scores: E(): 5.8e-30, 65.71% id in 105 aa.
 
  
 0.656
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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