STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rspAPutative starvation sensing mandelate racemase / muconate lactonizing enzyme; Similar to Escherichia coli starvation sensing protein RspA SWALL:RSPA_ECOLI (SWALL:P38104) (404 aa) fasta scores: E(): 5.7e-163, 92.57% id in 404 aa. Also similar to ECA0189 (36.070% id. in 402 aa overlap). (411 aa)    
Predicted Functional Partners:
ECA0920
Probable carbohydrate oxidoreductase; Similar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 1.5e-102, 54.83% id in 476 aa, and to Escherichia coli hypothetical oxidoreductase ydfi or b1542 SWALL:YDFI_ECOLI (SWALL:P77260) (486 aa) fasta scores: E(): 1.2e-127, 65.26% id in 475 aa. Also similar to ECA0819 (UxuB) (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family.
 
  
 0.942
uxuB
Similar to Escherichia coli D-mannonate oxidoreductase UxuB or b4323 SWALL:UXUB_ECOLI (SWALL:P39160) (486 aa) fasta scores: E(): 4.5e-107, 56.03% id in 489 aa, and to Yersinia pestis putative D-mannonate oxidoreductase ypo1280 or y2903 SWALL:AAM86454 (EMBL:AJ414147) (490 aa) fasta scores: E(): 8.7e-128, 63.93% id in 488 aa. Also similar to ECA0920 (54.906% id. in 479 aa overlap); Belongs to the mannitol dehydrogenase family.
 
  
 0.923
ECA0189
Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
  
  
 
0.912
uxuA
Mannonate dehydratase; Catalyzes the dehydration of D-mannonate; Belongs to the mannonate dehydratase family.
    
 0.907
uxaA
Similar to Escherichia coli altronate hydrolase UxaA SWALL:UXAA_ECOLI (SWALL:P42604) (495 aa) fasta scores: E(): 4.1e-163, 80.24% id in 496 aa.
    
 0.906
kduD
2-keto-3-deoxygluconate oxidoreductase; Similar to Pectobacterium carotovorum subsp. atrosepticum 2-keto-3-deoxygluconate oxidoreductase KduD SWALL:Q8KHI5 (EMBL:AJ506783) (253 aa) fasta scores: E(): 6.3e-94, 98.41% id in 253 aa, and to Erwinia chrysanthemi 2-deoxy-D-gluconate 3-dehydrogenase KduD SWALL:KDUD_ERWCH (SWALL:Q05528) (253 aa) fasta scores: E(): 4.4e-87, 89.72% id in 253 aa.
     
  0.900
kdgK
2-dehydro-3-deoxygluconokinase; Similar to Erwinia chrysanthemi 2-dehydro-3-deoxygluconokinase KdgK SWALL:KDGK_ERWCH (SWALL:P45416) (310 aa) fasta scores: E(): 1.4e-100, 82.25% id in 310 aa.
 
  
 0.851
rpiB
Ribose 5-phosphate isomerase; Involved in catabolism of D-apiose. Catalyzes the isomerization of D-erythrulose 4-phosphate to D-erythrose 4-phosphate.
     
  0.800
gnd
6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
     
  0.800
rpiA
Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
     
  0.800
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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