STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccdA2Cytotoxic protein (pseudogene); Pseudogene. This CDS appears to have a frameshift mutation. Similar to Escherichia coli, and Escherichia coli O157:H7 cytotoxic protein CcdB or LetB or protein G SWALL:CCDB_ECOLI (SWALL:P05703) (101 aa) fasta scores: E(): 5.9e-06, 44.06% id in 59 aa, and to Shigella flexneri CcdB protein SWALL:Q9AJV2 (EMBL:AL391753) (108 aa) fasta scores: E(): 8.7e-06, 42.37% id in 59 aa. (72 aa)    
Predicted Functional Partners:
ECA0964
Putative regulatory protein; Similar to Rhizobium loti hypothetical protein Msr0960 SWALL:Q98LM9 (EMBL:AP002996) (83 aa) fasta scores: E(): 2.2e-07, 43.47% id in 69 aa, and to Leptospira interrogans predicted transcriptional regulator la0511 SWALL:AAN47710 (EMBL:AE011237) (98 aa) fasta scores: E(): 1.5e-05, 45.9% id in 61 aa.
       0.746
ECA0965
Putative regulatory protein; Similar to Leptospira interrogans predicted transcriptional regulator la2845 SWALL:AAN50044 (EMBL:AE011449) (98 aa) fasta scores: E(): 6.8e-06, 50.82% id in 61 aa, and to Rhizobium loti hypothetical protein Msr0960 msr0960 SWALL:Q98LM9 (EMBL:AP002996) (83 aa) fasta scores: E(): 2.9e-07, 45.45% id in 66 aa.
       0.532
parE
Topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
      
 0.498
murA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
      
 0.485
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
      
 0.471
tufB
Elongation factor Tu; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 elongation factor Tu TufB or b3980 or c4935 or z5553 or ecs4903 SWALL:EFTU_ECOLI (SWALL:P02990) (393 aa) fasta scores: E(): 5.5e-138, 95.42% id in 393 aa. Identical to ECA0216 (TufA) (100.000% id. in 394 aa overlap).
      
 0.470
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      
 0.459
recA
RecA protein (recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
      
 0.457
doc
Similar to Bacteriophage P1 death on curing protein Doc SWALL:DOC_BPP1 (SWALL:Q06259) (126 aa) fasta scores: E(): 1.5e-05, 37.61% id in 109 aa, and to Escherichia coli Doc protein Doc SWALL:Q47172 (EMBL:X98141) (126 aa) fasta scores: E(): 1.1e-05, 37.61% id in 109 aa.
     
 0.455
lexA
LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
      
 0.453
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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