| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ECA1019 | queF | ECA1019 | ECA1020 | Lysine decarboxylase family protein; Similar to Salmonella typhimurium putative nucleotide binding ygdh or stm2969 SWALL:Q8ZMD2 (EMBL:AE008836) (454 aa) fasta scores: E(): 4.8e-158, 86.78% id in 454 aa, and to Yersinia pestis hypothetical protein ypo1033 or y3148 SWALL:AAM86698 (EMBL:AJ414146) (454 aa) fasta scores: E(): 2e-157, 86.12% id in 454 aa. | Putative GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.579 |
| ECA1019 | syd | ECA1019 | ECA1021 | Lysine decarboxylase family protein; Similar to Salmonella typhimurium putative nucleotide binding ygdh or stm2969 SWALL:Q8ZMD2 (EMBL:AE008836) (454 aa) fasta scores: E(): 4.8e-158, 86.78% id in 454 aa, and to Yersinia pestis hypothetical protein ypo1033 or y3148 SWALL:AAM86698 (EMBL:AJ414146) (454 aa) fasta scores: E(): 2e-157, 86.12% id in 454 aa. | Putative SecY-interacting protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. | 0.476 |
| ECA1153 | queF | ECA1153 | ECA1020 | Putative exported protein; Similar to Salmonella typhimurium, and Salmonella typhi putative DNA uptake protein and related dna-binding proteins ybav or stm0453 or sty0495 SWALL:Q8XGV0 (EMBL:AE008716) (124 aa) fasta scores: E(): 5.3e-15, 48.78% id in 123 aa, and to Escherichia coli, and Shigella flexneri hypothetical protein ybav precursor ybav or b0442 or sf0387 SWALL:AAN42043 (EMBL:AE000150) (123 aa) fasta scores: E(): 2.8e-13, 49.19% id in 124 aa. | Putative GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.753 |
| ECA1153 | secY | ECA1153 | ECA4011 | Putative exported protein; Similar to Salmonella typhimurium, and Salmonella typhi putative DNA uptake protein and related dna-binding proteins ybav or stm0453 or sty0495 SWALL:Q8XGV0 (EMBL:AE008716) (124 aa) fasta scores: E(): 5.3e-15, 48.78% id in 123 aa, and to Escherichia coli, and Shigella flexneri hypothetical protein ybav precursor ybav or b0442 or sf0387 SWALL:AAN42043 (EMBL:AE000150) (123 aa) fasta scores: E(): 2.8e-13, 49.19% id in 124 aa. | Preprotein translocase subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.499 |
| ECA3553 | nrdG | ECA3553 | ECA0374 | Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM or b2765 or z4075 or ecs3620 or sf2781 SWALL:PTPS_ECOLI (SWALL:Q46903) (121 aa) fasta scores: E(): 8.1e-44, 86.66% id in 120 aa. | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.727 |
| ECA3553 | queC | ECA3553 | ECA1155 | Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM or b2765 or z4075 or ecs3620 or sf2781 SWALL:PTPS_ECOLI (SWALL:Q46903) (121 aa) fasta scores: E(): 8.1e-44, 86.66% id in 120 aa. | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)); Belongs to the QueC family. | 0.950 |
| ECA3553 | queE | ECA3553 | ECA3554 | Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM or b2765 or z4075 or ecs3620 or sf2781 SWALL:PTPS_ECOLI (SWALL:Q46903) (121 aa) fasta scores: E(): 8.1e-44, 86.66% id in 120 aa. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.986 |
| ECA3553 | queF | ECA3553 | ECA1020 | Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM or b2765 or z4075 or ecs3620 or sf2781 SWALL:PTPS_ECOLI (SWALL:Q46903) (121 aa) fasta scores: E(): 8.1e-44, 86.66% id in 120 aa. | Putative GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.806 |
| ECA3553 | tgt | ECA3553 | ECA1120 | Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM or b2765 or z4075 or ecs3620 or sf2781 SWALL:PTPS_ECOLI (SWALL:Q46903) (121 aa) fasta scores: E(): 8.1e-44, 86.66% id in 120 aa. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.413 |
| ECA4354 | queF | ECA4354 | ECA1020 | Putative membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. | Putative GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.762 |
| nrdG | ECA3553 | ECA0374 | ECA3553 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM or b2765 or z4075 or ecs3620 or sf2781 SWALL:PTPS_ECOLI (SWALL:Q46903) (121 aa) fasta scores: E(): 8.1e-44, 86.66% id in 120 aa. | 0.727 |
| nrdG | queC | ECA0374 | ECA1155 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)); Belongs to the QueC family. | 0.659 |
| nrdG | queF | ECA0374 | ECA1020 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Putative GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.798 |
| queC | ECA3553 | ECA1155 | ECA3553 | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)); Belongs to the QueC family. | Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM or b2765 or z4075 or ecs3620 or sf2781 SWALL:PTPS_ECOLI (SWALL:Q46903) (121 aa) fasta scores: E(): 8.1e-44, 86.66% id in 120 aa. | 0.950 |
| queC | nrdG | ECA1155 | ECA0374 | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)); Belongs to the QueC family. | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.659 |
| queC | queE | ECA1155 | ECA3554 | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)); Belongs to the QueC family. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.989 |
| queC | queF | ECA1155 | ECA1020 | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)); Belongs to the QueC family. | Putative GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.983 |
| queC | tgt | ECA1155 | ECA1120 | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)); Belongs to the QueC family. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.414 |
| queE | ECA3553 | ECA3554 | ECA3553 | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM or b2765 or z4075 or ecs3620 or sf2781 SWALL:PTPS_ECOLI (SWALL:Q46903) (121 aa) fasta scores: E(): 8.1e-44, 86.66% id in 120 aa. | 0.986 |
| queE | queC | ECA3554 | ECA1155 | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)); Belongs to the QueC family. | 0.989 |