STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECA1024Similar to Yersinia pestis hypothetical protein Ypo1037 SWALL:Q8ZH73 (EMBL:AJ414146) (110 aa) fasta scores: E(): 9.2e-20, 55.04% id in 109 aa, and to Salmonella typhi hypothetical protein yqcc or sty3104 SWALL:Q8Z438 (EMBL:AL627276) (109 aa) fasta scores: E(): 3.6e-15, 45.79% id in 107 aa. (116 aa)    
Predicted Functional Partners:
ECA1025
Putative RNA pseudouridylate synthase; Similar to Yersinia pestis hypothetical protein ypo1038 or y3143 SWALL:Q8ZH72 (EMBL:AJ414146) (257 aa) fasta scores: E(): 3.4e-82, 75.39% id in 256 aa, and to Escherichia coli O157:H7 hypothetical protein z4107 or ecs3651 SWALL:Q8X6T6 (EMBL:AE005507) (260 aa) fasta scores: E(): 1.4e-75, 71.37% id in 255 aa.
  
  
 0.887
ECA1026
Putative flavodoxin; Similar to Yersinia pestis hypothetical protein ypo1039 or y3142 SWALL:Q8ZH71 (EMBL:AJ414146) (149 aa) fasta scores: E(): 1.2e-39, 68.91% id in 148 aa, and to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri hypothetical protein yqca or b2790 or z4106 or ecs3650 or sf2803 SWALL:AAN44291 (EMBL:U29581) (149 aa) fasta scores: E(): 9.2e-37, 66.89% id in 148 aa.
       0.671
ECA1023
Similar to Neisseria meningitidis transcriptional regulator, MarR family nmb1585 SWALL:Q9JYH5 (EMBL:AE002509) (143 aa) fasta scores: E(): 1.1e-18, 40.71% id in 140 aa, and to Neisseria meningitidis putative transcriptional regulator nma1774 SWALL:Q9JTH6 (EMBL:AL162757) (120 aa) fasta scores: E(): 2.4e-15, 45.53% id in 112 aa.
       0.536
nfuA
Conserved hypothetical protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
  
     0.530
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
     0.526
thiI
Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
     0.484
sixA
Similar to Escherichia coli phosphohistidine phosphatase SixA or b2340 SWALL:SIXA_ECOLI (SWALL:P76502) (161 aa) fasta scores: E(): 6.1e-35, 66.02% id in 156 aa.
  
     0.455
nfi
Endonuclease V (pseudogene); 1 probable transmembrane helix predicted for ECA0236 by TMHMM2.0 at aa 102-124.
  
     0.429
sdhE
Conserved hypothetical protein; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
  
    0.411
ECA3518
Similar to Yersinia pestis hypothetical protein ypo3271 or y0918 SWALL:AAM84500 (EMBL:AJ414156) (249 aa) fasta scores: E(): 4.6e-56, 66.51% id in 218 aa, and to Shigella flexneri orf, conserved hypothetical protein yfip or sf2645 SWALL:AAN44141 (EMBL:AE015279) (249 aa) fasta scores: E(): 8.3e-54, 60.85% id in 235 aa.
  
     0.401
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.