STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
glnD[protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. (904 aa)    
Predicted Functional Partners:
glnB
Nitrogen regulatory protein P-II; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, Salmonella typhimurium, Salmonella typhi, and Shigella flexneri nitrogen regulatory protein P-II 1 SWALL:GLNB_ECOLI (SWALL:P05826) (112 aa) fasta scores: E(): 1e-37, 93.75% id in 112 aa; Belongs to the P(II) protein family.
 
 
 0.982
glnK
Nitrogen regulatory protein P-II; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri nitrogen regulatory protein P-II 2 GlnK or b0450 or c0568 or z0562 or ecs0504 or sf0395 SWALL:GLNK_ECOLI (SWALL:P38504) (112 aa) fasta scores: E(): 1.3e-34, 93.45% id in 107 aa; Belongs to the P(II) protein family.
 
 
 
 0.835
glnE
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
 
   
 0.796
dapD
Similar to Escherichia coli, and Shigella flexneri 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase DapD or b0166 or sf0156 SWALL:DAPD_ECOLI (SWALL:P03948) (274 aa) fasta scores: E(): 4.7e-99, 91.94% id in 273 aa, and to Salmonella typhimurium 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase DapD or stm0213 SWALL:Q8ZRP4 (EMBL:AE008704) (274 aa) fasta scores: E(): 2e-98, 90.11% id in 273 aa; Belongs to the transferase hexapeptide repeat family.
     
 0.755
gltB
Similar to Escherichia coli glutamate synthase [NADPH] large chain precursor GltB or AspB SWALL:GLTB_ECOLI (SWALL:P09831) (1517 aa) fasta scores: E(): 0, 86.75% id in 1495 aa, and to Yersinia pestis glutamate synthase, large subunit GltB SWALL:AAM83722 (EMBL:AE013613) (1535 aa) fasta scores: E(): 0, 90.25% id in 1498 aa.
 
   
 0.654
glnL
Nitrogen regulation two-component system, histidine kinase; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri nitrogen regulation protein nr(II) GlnL or NtrB or GlnR SWALL:AAN45374 (EMBL:X05173) (349 aa) fasta scores: E(): 1.2e-108, 84.81% id in 349 aa.
  
 
 
 0.631
map
Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
  
    0.620
ECA1027
Similar to Yersinia pestis hypothetical protein ypo1040 or y3141 SWALL:AAM86691 (EMBL:AJ414146) (129 aa) fasta scores: E(): 3.2e-38, 84.49% id in 129 aa, and to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri hypothetical protein yaeh or b0163 or c0200 or z0175 or ecs0167 or sf0155 SWALL:AAN41817 (EMBL:D26562) (128 aa) fasta scores: E(): 8.4e-38, 85.82% id in 127 aa; Belongs to the UPF0325 family.
       0.598
glnA
Glutamine synthetase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri glutamine synthetase GlnA or b3870 or c4819 or z5406 or ecs4792 or sf3940 SWALL:GLNA_ECOLI (SWALL:P06711) (468 aa) fasta scores: E(): 3e-170, 90.17% id in 468 aa.
 
   
 0.597
ecfK
Putative surface antigen; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.
 
    0.540
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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