STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mutSDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (854 aa)    
Predicted Functional Partners:
mutL
DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
 
 0.992
ECA0649
Weakly similar to Schizosaccharomyces pombe putative DNA mismatch repair protein, mlh1 homolog spbc1703.04 SWALL:Q9P7W6 (EMBL:AL136536) (684 aa) fasta scores: E(): 0.11, 21.48% id in 498 aa, and to Neisseria meningitidis hypothetical protein Nma0428 nma0428 SWALL:Q9JWD7 (EMBL:AL162753) (548 aa) fasta scores: E(): 0.18, 22.37% id in 523 aa.
  
 0.964
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
  
 0.955
polA
Putative DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.942
xni
Exodeoxyribonuclease IX; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
   
 0.887
recQ
Similar to Escherichia coli ATP-dependent DNA helicase RecQ or b3822 SWALL:RECQ_ECOLI (SWALL:P15043) (607 aa) fasta scores: E(): 1.4e-198, 80.66% id in 605 aa.
  
 0.669
ECA0593
Similar to Vibrio cholerae DNA repair protein RadC homolog SWALL:RADC_VIBCH (SWALL:Q9KVC9) (224 aa) fasta scores: E(): 2.2e-28, 55.47% id in 137 aa, and to Escherichia coli DNA repair protein RadC SWALL:RADC_ECOLI (SWALL:P25531) (222 aa) fasta scores: E(): 2.4e-26, 50.38% id in 129 aa; Belongs to the UPF0758 family.
 
   
 0.612
radC
DNA repair protein; Similar to Escherichia coli DNA repair protein RadC or b3638 SWALL:RADC_ECOLI (SWALL:P25531) (222 aa) fasta scores: E(): 1.1e-50, 58.14% id in 215 aa; Belongs to the UPF0758 family. YicR subfamily.
 
   
 0.610
ECA2855
Conserved hypothetical protein; Similar to Shigella flexneri intergenic-region protein yees or sf2996 SWALL:AAN44477 (EMBL:AE015313) (163 aa) fasta scores: E(): 4.9e-27, 50.65% id in 152 aa, and to Escherichia coli intergenic-region protein SWALL:Q8VRA3 (EMBL:AF447814) (163 aa) fasta scores: E(): 5.7e-27, 50.65% id in 152 aa, and to Escherichia coli DNA repair protein RadC or b3638 SWALL:RADC_ECOLI (SWALL:P25531) (222 aa) fasta scores: E(): 5.6e-23, 47.51% id in 141 aa; Belongs to the UPF0758 family.
 
   
 0.602
recJ
Similar to Escherichia coli single-stranded-DNA-specific exonuclease RecJ SWALL:RECJ_ECOLI (SWALL:P21893) (577 aa) fasta scores: E(): 3.5e-163, 71.03% id in 580 aa, and to Erwinia chrysanthemi single-stranded-DNA-specific exonuclease RecJ SWALL:RECJ_ERWCH (SWALL:P39693) (575 aa) fasta scores: E(): 6.8e-178, 78.44% id in 580 aa.
 
  
 0.575
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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