STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ribDRiboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (369 aa)    
Predicted Functional Partners:
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
 0.998
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
 
 0.997
ECA1923
Riboflavin synthase alpha chain; Similar to Escherichia coli, and Shigella flexneri riboflavin synthase alpha chain RibE or RibC or b1662 or sf1690 SWALL:RISA_ECOLI (SWALL:P29015) (213 aa) fasta scores: E(): 7e-61, 76.84% id in 203 aa.
  
 0.997
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.
 
 
 0.995
ECA4180
Putative hydrolase; Similar to Escherichia coli, and Shigella flexneri hypothetical protein yigb or b3812 or sf3890 SWALL:YIGB_ECOLI (SWALL:P23306) (238 aa) fasta scores: E(): 1.4e-60, 66.8% id in 238 aa, and to Yersinia pestis putative haloacid dehalogenase-like hydrolase ypo3842 or y0388 SWALL:Q8ZAG0 (EMBL:AJ414159) (238 aa) fasta scores: E(): 3.4e-60, 66.38% id in 238 aa.
    
 0.942
nrdR
Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
  
  
 0.836
nusB
N utilization substance protein B; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
  
  
 0.757
accC
Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
   
   0.742
ECA1917
Putative allophanate hydrolase; Similar to the C-terminal region of Saccharomyces cerevisiae urea amidolyase [includes: urea carboxylase and allophanate hydrolase Dur1,2 or ybr208c or ybr1448 SWALL:DUR1_YEAST (SWALL:P32528) (1835 aa) fasta scores: E(): 3.6e-203, 44.47% id in 1212 aa, and to Caulobacter crescentus urea amidolyase-related protein cc1829 SWALL:Q9A797 (EMBL:AE005857) (1207 aa) fasta scores: E(): 0, 56.38% id in 1206 aa.
   
   0.742
ribF
Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri riboflavin biosynthesis protein ribf [includes: riboflavin kinase; FMN adenylyltransferase] RibF or b0025 or c0029 or z0029 or ecs0028 or sf0021 SWALL:RIBF_ECOLI (SWALL:P08391) (313 aa) fasta scores: E(): 2.3e-89, 76.03% id in 313 aa.
 
  
 0.738
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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