STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Coexpression
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[Homology]
Score
panE2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (302 aa)    
Predicted Functional Partners:
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
 
  
 0.984
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
    
 0.982
ECA1579
Probable ketopantoate reductase; Similar to Escherichia coli, and Shigella flexneri 2-dehydropantoate 2-reductase PanE or ApbA or b0425 or sf0362 SWALL:PANE_ECOLI (SWALL:P77728) (303 aa) fasta scores: E(): 0.016, 24.29% id in 284 aa, and to Mycobacterium tuberculosis putative 2-dehydropantoate 2-reductase rv2573 or mt2649 or mtcy227.28C SWALL:PANE_MYCTU (SWALL:Q50648) (295 aa) fasta scores: E(): 5.3e-56, 51.2% id in 291 aa. Also similar to ECA1136 (24.101% id in 278 aa overlap).
  
  
  0.953
thiJ
Similar to Escherichia coli 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme ThiJ or b0424 SWALL:THIJ_ECOLI (SWALL:Q46948) (196 aa) fasta scores: E(): 8.7e-55, 70.91% id in 196 aa.
       0.804
ECA1137
Similar to Yersinia pestis hypothetical protein Ypo3170 SWALL:Q8ZC52 (EMBL:AJ414155) (166 aa) fasta scores: E(): 7.7e-46, 84.66% id in 163 aa, and to Pasteurella multocida hypothetical protein Pm1656 SWALL:Q9CKG2 (EMBL:AE006202) (163 aa) fasta scores: E(): 1.9e-40, 74.23% id in 163 aa; Belongs to the UPF0234 family.
       0.590
alkB
Similar to Escherichia coli alkylated DNA repair protein AlkB or AidD or b2212 SWALL:ALKB_ECOLI (SWALL:P05050) (216 aa) fasta scores: E(): 6e-49, 56.94% id in 216 aa.
   
    0.553
folK
Similar to Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK or b0142 SWALL:HPPK_ECOLI (SWALL:P26281) (158 aa) fasta scores: E(): 1.5e-39, 67.08% id in 158 aa.
    
 0.448
ECA0189
Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
   
    0.413
rspA
Putative starvation sensing mandelate racemase / muconate lactonizing enzyme; Similar to Escherichia coli starvation sensing protein RspA SWALL:RSPA_ECOLI (SWALL:P38104) (404 aa) fasta scores: E(): 5.7e-163, 92.57% id in 404 aa. Also similar to ECA0189 (36.070% id. in 402 aa overlap).
   
    0.413
ECA2965
Putative mandelate racemase / muconate lactonizing enzyme; Similar to Streptomyces coelicolor putative isomerase sco3475 or sce65.11c or sce56.11C SWALL:Q9RKG2 (EMBL:AL939116) (377 aa) fasta scores: E(): 1.1e-43, 39.08% id in 394 aa, and to Oceanobacillus iheyensis hypothetical protein ob2215 SWALL:BAC14171 (EMBL:AP004600) (382 aa) fasta scores: E(): 6.9e-41, 36.36% id in 396 aa.
   
    0.413
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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