STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
panE2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (302 aa)    
Predicted Functional Partners:
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
 
  
 0.935
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
    
 0.925
ECA1579
Probable ketopantoate reductase; Similar to Escherichia coli, and Shigella flexneri 2-dehydropantoate 2-reductase PanE or ApbA or b0425 or sf0362 SWALL:PANE_ECOLI (SWALL:P77728) (303 aa) fasta scores: E(): 0.016, 24.29% id in 284 aa, and to Mycobacterium tuberculosis putative 2-dehydropantoate 2-reductase rv2573 or mt2649 or mtcy227.28C SWALL:PANE_MYCTU (SWALL:Q50648) (295 aa) fasta scores: E(): 5.3e-56, 51.2% id in 291 aa. Also similar to ECA1136 (24.101% id in 278 aa overlap).
  
  
  0.916
thiJ
Similar to Escherichia coli 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme ThiJ or b0424 SWALL:THIJ_ECOLI (SWALL:Q46948) (196 aa) fasta scores: E(): 8.7e-55, 70.91% id in 196 aa.
       0.791
ECA1137
Similar to Yersinia pestis hypothetical protein Ypo3170 SWALL:Q8ZC52 (EMBL:AJ414155) (166 aa) fasta scores: E(): 7.7e-46, 84.66% id in 163 aa, and to Pasteurella multocida hypothetical protein Pm1656 SWALL:Q9CKG2 (EMBL:AE006202) (163 aa) fasta scores: E(): 1.9e-40, 74.23% id in 163 aa; Belongs to the UPF0234 family.
       0.564
alkB
Similar to Escherichia coli alkylated DNA repair protein AlkB or AidD or b2212 SWALL:ALKB_ECOLI (SWALL:P05050) (216 aa) fasta scores: E(): 6e-49, 56.94% id in 216 aa.
   
    0.557
birA
Bira bifunctional protein [includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
     
 0.409
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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