STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECA1156Similar to Yersinia pestis putative pyridoxal-phosphate dependent protein ypo3147 or y1037 SWALL:Q8ZC75 (EMBL:AJ414155) (346 aa) fasta scores: E(): 1.4e-117, 83.47% id in 345 aa, and to Salmonella typhimurium putative cysteine synthase/cystathionine beta-synthase stm0458 SWALL:Q8ZRB5 (EMBL:AE008717) (351 aa) fasta scores: E(): 1.6e-105, 76.38% id in 343 aa. (358 aa)    
Predicted Functional Partners:
cysE
Serine acetyltransferase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri serine acetyltransferase CysEor b3607 or c4429 or z5034 or ecs4485 or sf3646 SWALL:CYSE_ECOLI (SWALL:P05796) (273 aa) fasta scores: E(): 5.1e-90, 86.08% id in 273 aa, and to Yersinia pestis serine acetyltransferase CysE SWALL:Q8ZJM4 (EMBL:AJ414141) (273 aa) fasta scores: E(): 1.5e-92, 89.37% id in 273 aa.
  
 0.989
cysJ
Sulfite reductase [NADPH] flavoprotein alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
  
 
 0.986
cysI
Sulfite reductase [NADPH] hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
 
 0.985
metB
Similar to Escherichia coli cystathionine gamma-synthase MetB or b3939 SWALL:METB_ECOLI (SWALL:P00935) (386 aa) fasta scores: E(): 3.8e-129, 87.01% id in 385 aa.
 
 0.981
metC
Similar to Escherichia coli cystathionine beta-lyase MetC or b3008 SWALL:METC_ECOLI (SWALL:P06721) (395 aa) fasta scores: E(): 8.3e-124, 73.85% id in 394 aa.
  
 0.978
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.961
luxS
Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
  
 
 0.957
sseA
Similar to Escherichia coli 3-mercaptopyruvate sulfurtransferase SseA or b2521 SWALL:THTM_ECOLI (SWALL:P31142) (280 aa) fasta scores: E(): 2.5e-67, 59.19% id in 272 aa.
  
 
 0.956
ECA0820
Similar to Emericella nidulans O-acetyl-L-homoserine sulfhydrylase CysD SWALL:O13387 (EMBL:AF029318) (437 aa) fasta scores: E(): 2.6e-79, 52.47% id in 425 aa, and to Shewanella oneidensis O-acetylhomoserine so1095 SWALL:AAN54166 (EMBL:AE015554) (430 aa) fasta scores: E(): 3.2e-138, 85.21% id in 426 aa.
  
 
 0.952
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 
 0.949
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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