STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (185 aa)    
Predicted Functional Partners:
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
  
 0.989
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase; Similar to Escherichia coli bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase] PurH or b4006 SWALL:PUR9_ECOLI (SWALL:P15639) (529 aa) fasta scores: E(): 3.7e-184, 88.84% id in 529 aa.
 
 0.962
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.953
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
 
 
 0.950
purB
Adenylosuccinate lyase; Similar to Escherichia coli, and Escherichia coli O6 adenylosuccinate lyase PurB or b1131 or c1510 SWALL:PUR8_ECOLI (SWALL:P25739) (456 aa) fasta scores: E(): 1.8e-159, 88.81% id in 456 aa.
  
 0.945
gpt
Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
  
 
 0.939
ECA4197
Probable lyase; Similar to Bacillus subtilis adenylosuccinate lyase PurB or PurE SWALL:PUR8_BACSU (SWALL:P12047) (431 aa) fasta scores: E(): 1.2e-45, 34.97% id in 406 aa, and to Pseudomonas aeruginosa probable lyase pa3517 SWALL:Q9HY92 (EMBL:AE004772) (477 aa) fasta scores: E(): 7.9e-71, 43.94% id in 446 aa.
  
 0.938
ECA3005
Similar to Ralstonia solanacearum putative glutamine amidotransferase protein rsc0213 or rs00645 SWALL:Q8Y2W9 (EMBL:AL646058) (238 aa) fasta scores: E(): 9e-37, 45.37% id in 238 aa, and to Xylella fastidiosa GMP synthase xf0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 1.1e-28, 43.8% id in 242 aa.
  
 
 0.929
hpt
Similar to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt or stm0170 SWALL:HPRT_SALTY (SWALL:O33799) (178 aa) fasta scores: E(): 1.2e-54, 86.2% id in 174 aa, and to Escherichia coli, Escherichia coli O6, and Shigella flexneri hypoxanthine phosphoribosyltransferase Hpt or b0125 or c0154 or sf0122 SWALL:HPRT_ECOLI (SWALL:P36766) (178 aa) fasta scores: E(): 2.4e-54, 84.48% id in 174 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
   
 0.927
guaC
GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
  
 
 0.927
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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