STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ubiG3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (241 aa)    
Predicted Functional Partners:
visC
Putative monooxygenase; Similar to Escherichia coli protein VisC or b2906 SWALL:VISC_ECOLI (SWALL:P25535) (400 aa) fasta scores: E(): 3.8e-114, 72.43% id in 399 aa.
 
 
 0.978
visB
Similar to Escherichia coli 2-octaprenyl-6-methoxyphenol hydroxylase UbiH or VisB or b2907 SWALL:UBIH_ECOLI (SWALL:P25534) (392 aa) fasta scores: E(): 2.4e-96, 62.24% id in 392 aa.
 
 
 0.977
ubiF
Similar to Escherichia coli 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase UbiF or b0662 SWALL:UBIF_ECOLI (SWALL:P75728) (391 aa) fasta scores: E(): 4.8e-94, 65.7% id in 382 aa.
 
 
 0.974
ubiA
4-hydroxybenzoate octaprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
 
 
 0.797
ubiE
Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).
 
 
 0.726
ubiB
Probable ubiquinone biosynthesis protein; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
  
 
 0.659
ECA0837
Similar to Yersinia pestis hypothetical protein ypo1102 SWALL:Q8ZH13 (EMBL:AJ414146) (144 aa) fasta scores: E(): 2.3e-47, 86.01% id in 143 aa, and to Escherichia coli, and Shigella flexneri hypothetical protein YfjG SWALL:AAN44173 (EMBL:D12501) (158 aa) fasta scores: E(): 3.3e-42, 76.55% id in 145 aa.
  
   
 0.639
ECA2170
Similar to Escherichia coli O6 hypothetical protein c3243 SWALL:AAN81695 (EMBL:AE016765) (370 aa) fasta scores: E(): 3.8e-47, 38.31% id in 355 aa, and to Clostridium acetobutylicum polya polymerase related protein cac0753 SWALL:Q97L13 (EMBL:AE007591) (363 aa) fasta scores: E(): 4e-41, 35.24% id in 349 aa.
   
   0.626
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.616
rcsC
Two-component system sensor protein; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB.
   
 
 0.558
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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