STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hybCHydrogenase-2 large subunit; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri hydrogenase-2 large chain precursor HybC or b2994 or z4348 or ecs3879 or sf3041 SWALL:MBHM_ECOLI (SWALL:P37181) (566 aa) fasta scores: E(): 2e-178, 73.85% id in 566 aa; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (564 aa)    
Predicted Functional Partners:
hybO
Hydrogenase-2 small subunit; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 hydrogenase-2 small chain precursor hybO or b2997 or c3734 or z4351 or ecs3882 SWALL:MBHT_ECOLI (SWALL:Q46847) (372 aa) fasta scores: E(): 2.9e-121, 80.75% id in 369 aa.
 
 0.999
hybD
Similar to Escherichia coli hydrogenase 2 maturation protease HybD or b2993 SWALL:HYBD_ECOLI (SWALL:P37182) (164 aa) fasta scores: E(): 1.7e-36, 67.7% id in 161 aa.
 
 
 0.980
hybB
Similar to Escherichia coli probable Ni/Fe-hydrogenase 2 B-type cytochrome subunit hybb or b2995 SWALL:HYBB_ECOLI (SWALL:P37180) (392 aa) fasta scores: E(): 8.4e-123, 73.69% id in 384 aa.
 
  
 0.962
hybE
Hydrogenase-2 component protein; Similar to Escherichia coli, and Escherichia coli O6 hydrogenase-2 operon protein HybE or b2992 or c3729 SWALL:HYBE_ECOLI (SWALL:P37183) (162 aa) fasta scores: E(): 1.3e-27, 48.05% id in 154 aa.
 
  
 0.958
hypA
Putative regulator of hydrogenase isoenzymes; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.955
hybA
Hydrogenase-2 operon protein; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri hydrogenase-2 operon protein hyba precursor HybA or b2996 or z4350 or ecs3881 or sf3043 SWALL:HYBA_ECOLI (SWALL:P37179) (328 aa) fasta scores: E(): 4.3e-93, 70.23% id in 336 aa.
 
  
 0.950
ECA0824
Similar to Rhodospirillum rubrum pyruvate-flavodoxin oxidoreductase NifJ SWALL:NIFJ_RHORU (SWALL:Q53046) (1191 aa) fasta scores: E(): 0, 54.73% id in 1182 aa, and to Escherichia coli probable pyruvate-flavodoxin oxidoreductase ydbk or b1378 SWALL:NIFJ_ECOLI (SWALL:P52647) (1174 aa) fasta scores: E(): 0, 78.79% id in 1174 aa. Also similar to ECA2957 (47.377% id. in 1182 aa overlap).
  
  
 0.941
hypD
Similar to Escherichia coli hydrogenase isoenzymes formation protein HypD or b2729 SWALL:HYPD_ECOLI (SWALL:P24192) (373 aa) fasta scores: E(): 2.4e-119, 76.55% id in 371 aa; Belongs to the HypD family.
 
 
 0.887
hypF
Hydrogenase maturation protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
 
 
 0.861
hypB
Similar to Escherichia coli, and Escherichia coli O6 hydrogenase isoenzymes nickel incorporation protein HypB or b2727 or c3287 SWALL:HYPB_ECOLI (SWALL:P24190) (290 aa) fasta scores: E(): 5.3e-95, 81.09% id in 291 aa.
 
  
 0.858
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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