STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dapESuccinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa)    
Predicted Functional Partners:
dapF
Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.
    
 0.935
argD
Acetylornithine/succinyldiaminopimelate aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
  
 
 0.917
ECA1292
Conserved hypothetical protein; Similar to Escherichia coli protein yffb or b2471 SWALL:YFFB_ECOLI (SWALL:P24178) (118 aa) fasta scores: E(): 8e-24, 61.15% id in 121 aa, and to Yersinia pestis hypothetical protein ypo3052 or y1428 SWALL:Q8ZCD9 (EMBL:AJ414155) (132 aa) fasta scores: E(): 1.1e-27, 67.5% id in 120 aa; Belongs to the ArsC family.
  
    0.829
ECA1290
Similar to Yersinia pestis putative carboxypeptidase ypo3054 or y1426 SWALL:Q8ZCD7 (EMBL:AJ414155) (225 aa) fasta scores: E(): 1.8e-65, 68.34% id in 218 aa, and to Pasteurella multocida hypothetical protein Pm1021 SWALL:Q9CM23 (EMBL:AE006143) (228 aa) fasta scores: E(): 8.7e-46, 51.13% id in 221 aa.
     
 0.802
ECA1289
Similar to Yersinia pestis putative membrane protein ypo3055 SWALL:Q8ZCD6 (EMBL:AJ414155) (64 aa) fasta scores: E(): 1.4e-19, 73.84% id in 65 aa, and to Salmonella typhimurium, and Salmonella typhi putative inner membrane protein stm2484 or sty2722 SWALL:Q8XF02 (EMBL:AE008812) (66 aa) fasta scores: E(): 5.5e-17, 66.12% id in 62 aa.
     
 0.787
dnaQ
DNA polymerase III, epsilon chain; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.
  
   
 0.604
prmB
Conserved hypothetical protein; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
 
  
 0.601
cca
tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
  
     0.560
rrmA
Similar to Escherichia coli ribosomal RNA large subunit methyltransferase A RrmA or b1822 SWALL:RRMA_ECOLI (SWALL:P36999) (269 aa) fasta scores: E(): 2.3e-62, 60.37% id in 270 aa.
  
    0.556
dapD
Similar to Escherichia coli, and Shigella flexneri 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase DapD or b0166 or sf0156 SWALL:DAPD_ECOLI (SWALL:P03948) (274 aa) fasta scores: E(): 4.7e-99, 91.94% id in 273 aa, and to Salmonella typhimurium 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase DapD or stm0213 SWALL:Q8ZRP4 (EMBL:AE008704) (274 aa) fasta scores: E(): 2e-98, 90.11% id in 273 aa; Belongs to the transferase hexapeptide repeat family.
 
  
 0.541
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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