STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
sucA2-oxoglutarate dehydrogenase E1 component; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 2-oxoglutarate dehydrogenase E1 component SucA or b0726 or c0803 or z0880 or ecs0751 SWALL:ODO1_ECOLI (SWALL:P07015) (933 aa) fasta scores: E(): 0, 83.42% id in 935 aa. (935 aa)    
Predicted Functional Partners:
sucB
Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.999
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.998
sucD
succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.997
icd
Similar to Escherichia coli isocitrate dehydrogenase [NADP] Icd or IcdA or IcdE or b1136 SWALL:IDH_ECOLI (SWALL:P08200) (416 aa) fasta scores: E(): 1.7e-143, 88.01% id in 417 aa.
   
 0.995
lpdA
Dihydrolipoamide dehydrogenase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri dihydrolipoamide dehydrogenase LpdA or Lpd or b0116 or c0145 or z0126 or ecs0120 or sf0113 SWALL:DLDH_ECOLI (SWALL:P00391) (473 aa) fasta scores: E(): 1.6e-169, 95.77% id in 473 aa.
 
 0.994
aceF
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.980
sdhB
Similar to Escherichia coli succinate dehydrogenase iron-sulfur protein SdhB or b0724 SWALL:DHSB_ECOLI (SWALL:P07014) (238 aa) fasta scores: E(): 6.3e-88, 87.81% id in 238 aa; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 
 0.978
gltB
Similar to Escherichia coli glutamate synthase [NADPH] large chain precursor GltB or AspB SWALL:GLTB_ECOLI (SWALL:P09831) (1517 aa) fasta scores: E(): 0, 86.75% id in 1495 aa, and to Yersinia pestis glutamate synthase, large subunit GltB SWALL:AAM83722 (EMBL:AE013613) (1535 aa) fasta scores: E(): 0, 90.25% id in 1498 aa.
     
 0.975
sdhC
Similar to Escherichia coli, and Escherichia coli O157:H7 succinate dehydrogenase cytochrome b-556 subunit SdhC or CybA or b0721 or z0875 or ecs0746 SWALL:DHSC_ECOLI (SWALL:P10446) (129 aa) fasta scores: E(): 1.1e-38, 79.06% id in 129 aa.
 
  
 0.973
sdhD
Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
 
  
 0.970
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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