STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tolATolA protein; Similar to Erwinia chrysanthemi TolA protein TolA SWALL:Q937K4 (EMBL:AJ297885) (395 aa) fasta scores: E(): 7.1e-61, 79.44% id in 394 aa, and to Escherichia coli tola protein TolA or Cim or ExcC or Lky or b0739 SWALL:TOLA_ECOLI (SWALL:P19934) (421 aa) fasta scores: E(): 6.5e-29, 58.72% id in 424 aa. (395 aa)    
Predicted Functional Partners:
lptC
Putative exported protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
     0.751
ECA1368
Putative membrane protein; Similar to Erwinia chrysanthemi YbgE protein SWALL:Q937K8 (EMBL:AJ297885) (97 aa) fasta scores: E(): 1.7e-31, 79.16% id in 96 aa, and to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri protein YbgE or b0735 or c0814 or z0903 or ecs0770 or sf0562 SWALL:YBGE_ECOLI (SWALL:P37343) (97 aa) fasta scores: E(): 4.2e-26, 63.54% id in 96 aa.
 
     0.729
tolR
tolR protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.
  
 
 0.702
tolB
TolB protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
  
 
 0.683
zapC
Conserved hypothetical protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
  
     0.682
ECA1145
Similar to Yersinia pestis putative lipoprotein ypo3161 or y1024 SWALL:AAM84605 (EMBL:AJ414155) (192 aa) fasta scores: E(): 7.8e-54, 80.2% id in 192 aa, and to Salmonella typhi putative lipoprotein sty0487 SWALL:Q8Z8V2 (EMBL:AL627266) (192 aa) fasta scores: E(): 2.3e-47, 68.75% id in 192 aa.
  
     0.675
ECA1369
Putative thioesterase; Similar to Yersinia pestis hypothetical protein ypo1120 or y3059 SWALL:Q8ZGZ5 (EMBL:AJ414146) (133 aa) fasta scores: E(): 5e-46, 87.21% id in 133 aa, and to Erwinia chrysanthemi YbgC protein SWALL:Q937K7 (EMBL:AJ297885) (134 aa) fasta scores: E(): 7.4e-45, 82.83% id in 134 aa.
 
     0.654
lapA
Putative membrane protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
  
     0.645
seqA
Putative negative regulator of replication initiation; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
    0.630
tolQ
TolQ protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.
  
   0.625
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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