Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
udkUridine kinase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri uridine kinase Udk or b2066 or c2593 or z3234 or ecs2873 or sf2130 SWALL:URK_ECOLI (SWALL:P31218) (213 aa) fasta scores: E(): 3e-70, 87.32% id in 213 aa. (213 aa)    
Predicted Functional Partners:
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
  
 0.988
cdd
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
    
 0.977
ushA
Similar to Escherichia coli protein UshA precursor [includes: UDP-sugar hydrolase and 5'-nucleotidase] UshA or b0480 SWALL:USHA_ECOLI (SWALL:P07024) (550 aa) fasta scores: E(): 1.6e-157, 71.5% id in 551 aa; Belongs to the 5'-nucleotidase family.
 
 
  0.968
ECA0053
Putative phosphodiesterase; Similar to Vibrio cholerae 2`,3`-cyclic-nucleotide 2`-phosphodiesterase, putative vc2416 SWALL:Q9KPF2 (EMBL:AE004311) (634 aa) fasta scores: E(): 9.2e-161, 66.4% id in 634 aa; Belongs to the 5'-nucleotidase family.
 
 
  0.965
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
   
 
 0.963
cmk
Cytidylate kinase; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 cytidylate kinase Cmk or MssA or b0910 or c1048 or z1256 or ecs0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 3.1e-66, 83.55% id in 225 aa.
   
 
 0.959
udp
Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family.
    
 0.956
ECA4424
Similar to Rhizobium meliloti putative nucleoside hydrolase protein r00415 or smc01105 SWALL:Q92SI0 (EMBL:AL591783) (314 aa) fasta scores: E(): 6.6e-47, 46.32% id in 313 aa, and to Agrobacterium tumefaciens inosine-uridine preferring nucleoside hydrolase iunh or atu0374 or agr_c_654 SWALL:Q8UIC3 (EMBL:AE009008) (333 aa) fasta scores: E(): 4.3e-50, 49.83% id in 309 aa; Belongs to the IUNH family.
   
 0.954
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
 
 0.951
ppnP
Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.
     
 0.946
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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