Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nahOAcetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (296 aa)    
Predicted Functional Partners:
nahM
4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 
 0.996
ECA0824
Similar to Rhodospirillum rubrum pyruvate-flavodoxin oxidoreductase NifJ SWALL:NIFJ_RHORU (SWALL:Q53046) (1191 aa) fasta scores: E(): 0, 54.73% id in 1182 aa, and to Escherichia coli probable pyruvate-flavodoxin oxidoreductase ydbk or b1378 SWALL:NIFJ_ECOLI (SWALL:P52647) (1174 aa) fasta scores: E(): 0, 78.79% id in 1174 aa. Also similar to ECA2957 (47.377% id. in 1182 aa overlap).
     
 0.948
nifV
Homocitrate synthase; Similar to Klebsiella pneumoniae homocitrate synthase NifV SWALL:NIFV_KLEPN (SWALL:P05345) (381 aa) fasta scores: E(): 1.8e-100, 68.94% id in 380 aa, and to Enterobacter agglomerans homocitrate synthase NifV SWALL:NIFV_ENTAG (SWALL:Q52070) (400 aa) fasta scores: E(): 1.6e-95, 68.4% id in 364 aa; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 0.881
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 0.881
pta
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
     
 0.842
adhE
Aldehyde-alcohol dehydrogenase; Similar to Escherichia coli, and Escherichia coli O157:H7 aldehyde-alcohol dehydrogenase [includes: alcohol dehydrogenase, acetaldehyde dehydrogenase, and pyruvate-formate-lyase deactivase AdhE or Ana or b1241 or z2016 or ecs1741 SWALL:ADHE_ECOLI (SWALL:P17547) (890 aa) fasta scores: E(): 0, 89.1% id in 890 aa; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
    
 0.830
ECA1430
Similar to Cicer arietinum dTDP-glucose 4-6-dehydratase SWALL:Q9SMJ5 (EMBL:AJ275318) (346 aa) fasta scores: E(): 1.7e-10, 28.52% id in 284 aa, and to Leptospira interrogans dTDP-glucose 4,6-dehydratase RfbB4 or la1661 SWALL:AAN48860 (EMBL:AE011344) (369 aa) fasta scores: E(): 1.2e-09, 28.67% id in 279 aa.
       0.776
ECA1426
Putative thiamine pyrophosphate enzyme; Similar to Bacillus subtilis acetolactate synthase large subunit IlvB SWALL:ILVB_BACSU (SWALL:P37251) (573 aa) fasta scores: E(): 5.9e-45, 32.32% id in 563 aa; Belongs to the TPP enzyme family.
 
   
 0.727
hpcH
Similar to Escherichia coli 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase HpcH or HpaI SWALL:HPAI_ECOLI (SWALL:Q47098) (262 aa) fasta scores: E(): 4.9e-22, 32.4% id in 250 aa; Belongs to the HpcH/HpaI aldolase family.
 
     0.715
napF
Ferredoxin-type protein; Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm; Belongs to the NapF family.
     
  0.704
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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