STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nahM4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (343 aa)    
Predicted Functional Partners:
nahO
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 
 0.998
ECA1426
Putative thiamine pyrophosphate enzyme; Similar to Bacillus subtilis acetolactate synthase large subunit IlvB SWALL:ILVB_BACSU (SWALL:P37251) (573 aa) fasta scores: E(): 5.9e-45, 32.32% id in 563 aa; Belongs to the TPP enzyme family.
 
 
 0.835
thrA
Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase I [includes: aspartokinase I; homoserine dehydrogenase I] thra or thra1 or thra2 or b0002 SWALL:AK1H_ECOLI (SWALL:P00561) (820 aa) fasta scores: E(): 0, 82.41% id in 819 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
  
 0.807
metL
Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase II MetL or MetM or b3940 SWALL:AK2H_ECOLI (SWALL:P00562) (809 aa) fasta scores: E(): 0, 83.12% id in 800 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
  
 0.803
ECA1430
Similar to Cicer arietinum dTDP-glucose 4-6-dehydratase SWALL:Q9SMJ5 (EMBL:AJ275318) (346 aa) fasta scores: E(): 1.7e-10, 28.52% id in 284 aa, and to Leptospira interrogans dTDP-glucose 4,6-dehydratase RfbB4 or la1661 SWALL:AAN48860 (EMBL:AE011344) (369 aa) fasta scores: E(): 1.2e-09, 28.67% id in 279 aa.
       0.773
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
  
 
 0.700
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
  
  
 0.687
ECA1427
Similar to Leptospira interrogans dTDP-glucose 4,6-dehydratase RfbB1 or la0235 SWALL:AAN47434 (EMBL:AE011212) (321 aa) fasta scores: E(): 0.0023, 23.05% id in 321 aa, and to Pyrococcus horikoshii 306aa long hypothetical UDP-glucose 4-epimerase ph1742 SWALL:O59375 (EMBL:AP000007) (306 aa) fasta scores: E(): 0.011, 28.63% id in 213 aa.
       0.682
ilvD
Similar to Escherichia coli dihydroxy-acid dehydratase IlvD or b3771 SWALL:ILVD_ECOLI (SWALL:P05791) (616 aa) fasta scores: E(): 9.7e-207, 87.98% id in 616 aa; Belongs to the IlvD/Edd family.
 
  
 0.680
hpcH
Similar to Escherichia coli 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase HpcH or HpaI SWALL:HPAI_ECOLI (SWALL:Q47098) (262 aa) fasta scores: E(): 4.9e-22, 32.4% id in 250 aa; Belongs to the HpcH/HpaI aldolase family.
       0.678
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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