Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rfbAGlucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (290 aa)    
Predicted Functional Partners:
rfbC
dTDP-6-deoxy-D-glucose-3,5 epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
 
 0.999
rffG
Similar to Escherichia coli dTDP-glucose 4,6-dehydratase RffG or b3788 SWALL:RFFG_ECOLI (SWALL:P27830) (355 aa) fasta scores: E(): 6.4e-119, 83% id in 353 aa; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.
 
 
 0.999
rfbD
dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family.
 
 
 0.996
ugd
Similar to Escherichia coli UDP-glucose 6-dehydrogenase Ugd or b2028 SWALL:UDG_ECOLI (SWALL:P76373) (388 aa) fasta scores: E(): 2.4e-110, 73.96% id in 388 aa, and to Vibrio cholerae nucleotide sugar dehydrogenase SWALL:Q56625 (EMBL:U47057) (388 aa) fasta scores: E(): 1e-110, 72.93% id in 388 aa.
  
 
 0.996
rfbM
Similar to Escherichia coli mannose-1-phosphate guanylyltransferase ManC or CpsB or RfbM or b2049 SWALL:MANC_ECOLI (SWALL:P24174) (478 aa) fasta scores: E(): 2.1e-114, 60.88% id in 473 aa, and to Shigella flexneri mannose-1-phosphate guanyltransferase CpsB_1 or sf2112 SWALL:AAN43651 (EMBL:AE015227) (478 aa) fasta scores: E(): 5.5e-115, 61.31% id in 473 aa; Belongs to the mannose-6-phosphate isomerase type 2 family.
  
 
 0.987
galF
Similar to Escherichia coli, and Escherichia coli O157:H7 UTP--glucose-1-phosphate uridylyltransferase GalF or WcaN or b2042 or z3205 or ecs2846 SWALL:GALF_ECOLI (SWALL:P78083) (297 aa) fasta scores: E(): 7.1e-74, 65.43% id in 298 aa, and to Salmonella typhimurium, and Salmonella typhi UTP--glucose-1-phosphate uridylyltransferase GalF or stm2098 or sty2308 SWALL:GALF_SALTY (SWALL:P26390) (297 aa) fasta scores: E(): 7.1e-74, 64.43% id in 298 aa.
  
 
 0.974
galE
Similar to Escherichia coli udp-glucose 4-epimerase GalE or GalD or b0759 SWALL:GALE_ECOLI (SWALL:P09147) (338 aa) fasta scores: E(): 5.5e-102, 76.03% id in 338 aa; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
    
 0.962
wecB
UDP-N-acetylglucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.
  
 
 0.962
glmU
Bifunctional GlmU protein [includes: UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferas [...]
    
 0.958
galU
UTP--glucose-1-phosphate uridylyltransferase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri UTP--glucose-1-phosphate uridylyltransferase GalU or b1236 or c1700 or z2012 or ecs1738 or sf1236 SWALL:GALU_ECOLI (SWALL:P25520) (301 aa) fasta scores: E(): 4.5e-98, 85.08% id in 295 aa, and to Erwinia chrysanthemi GalU protein galU SWALL:Q93KA5 (EMBL:AJ410309) (303 aa) fasta scores: E(): 1.1e-106, 92.69% id in 301 aa.
  
 
 0.954
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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