STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uhpBTwo-component system sensor histidine kinase; Similar to Escherichia coli sensor protein UhpB or b3668 SWALL:UHPB_ECOLI (SWALL:P09835) (500 aa) fasta scores: E(): 1e-25, 36.17% id in 528 aa, and to Vibrio cholerae sensor protein UhpB vca0683 SWALL:Q9KLQ9 (EMBL:AE004397) (527 aa) fasta scores: E(): 3.7e-66, 42.47% id in 518 aa. (525 aa)    
Predicted Functional Partners:
uhpA
Two-component system response regulator protein; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri transcriptional regulatory protein UhpA or b3669 or c4593 or z5159 or ecs4606 or sf3792 SWALL:UHPA_ECOLI (SWALL:P10940) (196 aa) fasta scores: E(): 1.2e-29, 48.98% id in 196 aa.
 
 0.994
narP
Similar to Escherichia coli nitrate/nitrite response regulator protein NarP or b2193 SWALL:NARP_ECOLI (SWALL:P31802) (215 aa) fasta scores: E(): 3e-46, 65.72% id in 213 aa.
 
 
 0.743
hrpY
Two-component response regulator; Similar to Erwinia chrysanthemi HrpY SWALL:Q8KUM3 (EMBL:AF448202) (213 aa) fasta scores: E(): 6.8e-57, 75.94% id in 212 aa, and to Erwinia amylovora response regulator HrpY SWALL:Q9X3S9 (EMBL:AF083877) (213 aa) fasta scores: E(): 1.3e-51, 69.34% id in 212 aa.
 
 
 0.722
narL
Nitrate/nitrite response regulator; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri nitrate/nitrite response regulator protein NarL or FrdR or b1221 or c1681 or z1996 or ecs1726 or sf1224 SWALL:NARL_ECOLI (SWALL:P10957) (216 aa) fasta scores: E(): 2.2e-60, 80.46% id in 215 aa.
 
 
 0.706
rcsB
Two-component response regulator; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions.
 
 
 0.701
expA
Two-component response regulator; Similar to Erwinia carotovora ExpA protein SWALL:O50326 (EMBL:X95564) (218 aa) fasta scores: E(): 1.3e-77, 98.62% id in 218 aa, and to Escherichia coli, and Shigella flexneri response regulator UvrY or b1914 or sf1957 SWALL:UVRY_ECOLI (SWALL:P07027) (218 aa) fasta scores: E(): 3.5e-65, 83.87% id in 217 aa. The Erwinia carotovora ExpA is involved in the global control of virulence.
 
 
 0.657
afuB
Ferric ABC transporter permease protein; Similar to Actinobacillus pleuropneumoniae ferric transport system permease protein AfuB SWALL:AFUB_ACTPL (SWALL:Q44123) (687 aa) fasta scores: E(): 8.6e-167, 64.73% id in 672 aa, and to Escherichia coli O157:H7 putative permease component of transport system for ferric iron AfuB or z0459 or ecs0414 SWALL:Q8X5J2 (EMBL:AE005215) (692 aa) fasta scores: E(): 2.1e-217, 81.21% id in 692 aa.
 
     0.637
evr
Virulence regulator; Similar to Pectobacterium carotovorum subsp. carotovorum virulence regulator Evr SWALL:AAN86997 (EMBL:AY167733) (204 aa) fasta scores: E(): 4.8e-39, 92.98% id in 114 aa. This CDS is truncated at the N-terminus relative to its orthologue in Pectobacterium carotovorum subsp. carotovorum.
 
 
 0.622
uhpC
Similar to Escherichia coli regulatory protein UhpC or b3667 SWALL:UHPC_ECOLI (SWALL:P09836) (439 aa) fasta scores: E(): 3.6e-99, 53.34% id in 433 aa, and to Yersinia pestis putative regulatory protein UhpC or ypo4007 SWALL:Q8ZA15 (EMBL:AJ414160) (443 aa) fasta scores: E(): 3.8e-103, 56.11% id in 417 aa.
 
    0.615
afuA
ABC transporter iron-binding protein; Similar to Actinobacillus pleuropneumoniae AfuA protein afuA SWALL:Q57512 (EMBL:U05042) (346 aa) fasta scores: E(): 1.4e-97, 69.56% id in 345 aa, and to Escherichia coli O157:H7 periplasmic ferric iron-binding protein AfuA or z0460 or ecs0415 SWALL:Q8X5J1 (EMBL:AE005215) (343 aa) fasta scores: E(): 4.2e-115, 84.01% id in 344 aa.
 
   
 0.609
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.