STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sulACell division inhibitor; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. (168 aa)    
Predicted Functional Partners:
recN
DNA repair protein; May be involved in recombinational repair of damaged DNA.
   
  
 0.914
ftsZ
Cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
    
 
 0.794
hslU
ATP-dependent Hsl protease ATP-binding subunit (heat shock protein); ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
    
   0.755
ECA4404
Similar to Yersinia pestis putative lipoprotein ypo4086 or y4103 SWALL:Q8Z9V4 (EMBL:AJ414160) (112 aa) fasta scores: E(): 2.8e-19, 55.35% id in 112 aa, and to Escherichia coli, and Shigella flexneri hypothetical protein yidq precursor yidq or b3688 or sf3775 SWALL:YIDQ_ECOLI (SWALL:P31454) (110 aa) fasta scores: E(): 1.2e-15, 46.55% id in 116 aa.
  
     0.701
secM
Secretion monitor precursor; Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation. Belongs to the SecM family.
  
     0.691
ECA0979
Putative exported protein; Similar to Salmonella typhimurium putative periplasmic protein yggn or stm3107 SWALL:Q8ZM42 (EMBL:AE008842) (239 aa) fasta scores: E(): 1.6e-48, 59.41% id in 239 aa, and to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 hypothetical protein yggn or b2958 or c3544 or z4303 or ecs3834 SWALL:YGGN_ECOLI (SWALL:P46143) (239 aa) fasta scores: E(): 1.8e-48, 58.99% id in 239 aa.
  
     0.689
ECA4348
Similar to Yersinia pestis putative membrane protein ypo3816a or y0414 SWALL:Q8ZAI5 (EMBL:AJ414159) (90 aa) fasta scores: E(): 1.2e-22, 71.59% id in 88 aa, and to Shigella flexneri orf, conserved hypothetical protein yhhl or sf3484 SWALL:AAN44943 (EMBL:AE015356) (90 aa) fasta scores: E(): 5.6e-22, 69.41% id in 85 aa.
  
     0.687
lexA
LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  
  
 0.665
ECA3332
Similar to Yersinia pestis putative exported protein ypo3410 or y0776 SWALL:Q8ZBJ9 (EMBL:AJ414157) (115 aa) fasta scores: E(): 1.6e-30, 69.29% id in 114 aa, and to Escherichia coli, and Escherichia coli O6 hypothetical protein yacc precursor yacc or b0122 or c0151 SWALL:YACC_ECOLI (SWALL:P23838) (115 aa) fasta scores: E(): 1.6e-27, 64.34% id in 115 aa.
  
     0.659
dinI
DNA-damage-inducible protein I; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri DNA-damage-inducible protein I DinI or b1061 or c1328 or z1698 or ecs1439 or sf1067 SWALL:DINI_ECOLI (SWALL:Q47143) (81 aa) fasta scores: E(): 6.5e-18, 64.19% id in 81 aa.
  
    0.645
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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