STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (347 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase catalytic subunit; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri aspartate carbamoyltransferase catalytic chain PyrB or b4245 or c5345 or z5856 or ecs5222 or sf4245 SWALL:PYRB_ECOLI (SWALL:P00479) (310 aa) fasta scores: E(): 7.7e-100, 85.43% id in 309 aa; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
   
 
 0.995
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
 
 
 0.995
pyrI
Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase.
   
 
  0.985
carB
Similar to Escherichia coli carbamoyl-phosphate synthase large chain CarB or PyrA or b0033 SWALL:CARB_ECOLI (SWALL:P00968) (1072 aa) fasta scores: E(): 0, 93.56% id in 1072 aa; Belongs to the CarB family.
   
 
 0.738
carA
Carbamoyl-phosphate synthase small chain; Similar to Escherichia coli, and Escherichia coli O157:H7 carbamoyl-phosphate synthase small chain CarA or PyrA or b0032 or z0037 or ecs0035 SWALL:CARA_ECOLI (SWALL:P00907) (382 aa) fasta scores: E(): 2e-130, 85.86% id in 382 aa; Belongs to the CarA family.
   
  
 0.723
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.683
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
  
 0.592
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 
 0.589
purM
Similar to Escherichia coli phosphoribosylformylglycinamidine cyclo-ligase PurM or PurG or b2499 SWALL:PUR5_ECOLI (SWALL:P08178) (344 aa) fasta scores: E(): 2.9e-117, 85.71% id in 343 aa.
   
  
 0.589
ECA0932
Permease; Similar to Escherichia coli, and Escherichia coli O6 cytosine permease CodB or b0336 or c0455 SWALL:CODB_ECOLI (SWALL:P25525) (419 aa) fasta scores: E(): 5.8e-25, 28.73% id in 428 aa, and to Streptomyces coelicolor putative cytosine permease sco0572 or sc5g5.04C SWALL:Q93RZ8 (EMBL:AL939106) (466 aa) fasta scores: E(): 2.4e-55, 40.19% id in 413 aa.
   
    0.556
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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