STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
thiKConserved hypothetical protein; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (275 aa)    
Predicted Functional Partners:
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
     
 0.977
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
     
 0.956
rsgA
Conserved hypothetical protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
 
  
  0.953
ECA4130
Alkaline phosphatase; Similar to Schizophyllum commune alkaline phosphatase Pho1 SWALL:Q9UR10 (EMBL:AF209194) (604 aa) fasta scores: E(): 5.3e-20, 32.91% id in 477 aa, and to Schizosaccharomyces pombe alkaline phosphatase spbc14f5.13C SWALL:PPB_SCHPO (SWALL:O60109) (532 aa) fasta scores: E(): 8.8e-15, 26.68% id in 491 aa.
     
  0.944
lpoB
Putative lipoprotein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family.
 
  
 0.800
ECA1810
Similar to Yersinia pestis putative lipoprotein ypo1612 SWALL:Q8ZFS6 (EMBL:AJ414149) (129 aa) fasta scores: E(): 1e-15, 44.53% id in 119 aa, and to Shigella flexneri orf, conserved hypothetical protein ycfl or sf1108 SWALL:AAN42726 (EMBL:AE015138) (125 aa) fasta scores: E(): 1.5e-14, 38.88% id in 126 aa.
     
 0.727
ECA1809
Similar to Yersinia pestis hypothetical protein ypo1611 ypo1611 or y1770 SWALL:Q8ZFS7 (EMBL:AJ414149) (117 aa) fasta scores: E(): 3.7e-38, 86.84% id in 114 aa, and to Salmonella typhimurium, and Salmonella typhi hypothetical protein ycff ycff or stm1205 or sty1245 SWALL:Q8XER7 (EMBL:AE008752) (119 aa) fasta scores: E(): 9.5e-38, 83.47% id in 115 aa.
     
 0.658
wecF
4-alpha-L-fucosyltransferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family.
 
   
 0.652
ECA4348
Similar to Yersinia pestis putative membrane protein ypo3816a or y0414 SWALL:Q8ZAI5 (EMBL:AJ414159) (90 aa) fasta scores: E(): 1.2e-22, 71.59% id in 88 aa, and to Shigella flexneri orf, conserved hypothetical protein yhhl or sf3484 SWALL:AAN44943 (EMBL:AE015356) (90 aa) fasta scores: E(): 5.6e-22, 69.41% id in 85 aa.
  
     0.624
nagZ
Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
  
    0.620
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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