STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECA1816Putative exported protein; Similar to Yersinia pestis hypothetical protein y1782 SWALL:AAM85350 (EMBL:AE013781) (188 aa) fasta scores: E(): 6.1e-55, 85.79% id in 183 aa, and to Escherichia coli, Escherichia coli O6, and Shigella flexneri hypothetical protein ycfj ycfj or b1110 or c1383 or sf1114 SWALL:AAN42732 (EMBL:AE000211) (192 aa) fasta scores: E(): 6.9e-52, 81.86% id in 182 aa. (189 aa)    
Predicted Functional Partners:
rseA
sigma-E factor negative regulator; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...]
   
    0.571
ECA0780
Putative exported protein; Similar to Xanthomonas campestris regulatory protein RpfI SWALL:Q8P9L0 (EMBL:AE012287) (342 aa) fasta scores: E(): 1.6e-36, 37.79% id in 344 aa. The Xanthomonas campestris RpfI is thought to be involved in the regulation of pathogenicity factor production. Note that there are no significant database matches to enterobacterial species.
   
  
 0.527
mzrA
Putative exported protein; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR.
  
     0.480
lpoA
Putative exported protein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family.
  
     0.456
entD
Enterobactin synthetase component D (4'-phosphopantetheinyl transferase); Similar to Escherichia coli 4'-phosphopantetheinyl transferase EntD or b0583 SWALL:ENTD_ECOLI (SWALL:P19925) (209 aa) fasta scores: E(): 4.1e-09, 31.49% id in 181 aa, and to Photorhabdus luminescens NgrA SWALL:Q9AI14 (EMBL:AF288077) (248 aa) fasta scores: E(): 2.9e-24, 34.32% id in 236 aa.
  
     0.452
ECA2255
Putative exported protein; Similar to Escherichia coli O157:H7 orf, hypothetical protein z2573 or ecs2292 SWALL:Q8X798 (EMBL:AE005382) (102 aa) fasta scores: E(): 1.2e-14, 55.44% id in 101 aa, and to Salmonella typhimurium putative outer membrane protein ynfd or stm1500 SWALL:Q8ZPJ5 (EMBL:AE008765) (102 aa) fasta scores: E(): 5.2e-14, 56.98% id in 93 aa.
  
    0.437
ligT
2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.
  
     0.434
aaeX
Putative membrane protein; Similar to Serratia marcescens hypothetical 7.8 kDa protein yhcR SWALL:Q8RQS4 (EMBL:AB080601) (67 aa) fasta scores: E(): 3.5e-20, 80.64% id in 62 aa, and to Yersinia pestis putative membrane protein ypo3684 or y0179 SWALL:Q8ZAV0 (EMBL:AJ414158) (67 aa) fasta scores: E(): 5.7e-20, 76.56% id in 64 aa.
  
     0.429
mtfA
Conserved hypothetical protein; Involved in the regulation of ptsG expression by binding and inactivating Mlc.
  
     0.410
rstB
Two component sensor kinase; Similar to Escherichia coli sensor protein RstB or UspT or b1609 SWALL:RSTB_ECOLI (SWALL:P18392) (433 aa) fasta scores: E(): 3.4e-113, 66.5% id in 424 aa.
  
     0.400
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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