Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
cobBPutative cobalamin biosynthesis/propionate catabolism protein; Similar to Salmonella typhimurium, and Salmonella typhi CobB protein CobB or stm1221 or sty1261 SWALL:COBB_SALTY (SWALL:P97013) (273 aa) fasta scores: E(): 1.4e-80, 74.81% id in 270 aa, and to Escherichia coli CobB protein CobB or b1120 SWALL:COBB_ECOLI (SWALL:P75960) (279 aa) fasta scores: E(): 3.9e-80, 74.44% id in 270 aa; Belongs to the sirtuin family. Class III subfamily. (276 aa)    
Predicted Functional Partners:
nadR
Similar to Salmonella typhimurium transcriptional regulator NadR SWALL:NADR_SALTY (SWALL:P24518) (410 aa) fasta scores: E(): 1.1e-140, 85.5% id in 407 aa, and to Escherichia coli transcriptional regulator NadR or NadI or b4390 SWALL:NADR_ECOLI (SWALL:P27278) (410 aa) fasta scores: E(): 2.2e-139, 83.9% id in 410 aa.
  
 
  0.996
nadD
Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 0.961
deoD
Purine nucleoside phosphorylase; Similar to Escherichia coli, and Escherichia coli O157:H7 purine nucleoside phosphorylase deoD or Pup or b4384 or z5986 or ecs5343 SWALL:DEOD_ECOLI (SWALL:P09743) (238 aa) fasta scores: E(): 2.1e-80, 89.07% id in 238 aa.
    
 0.957
nadE
NH3-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.956
ppnK
Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.954
pncA
Similar to Escherichia coli pyrazinamidase/nicotinamidase [includes: pyrazinamidase and nicotinamidase PncA or Nam or b1768 SWALL:PNCA_ECOLI (SWALL:P21369) (213 aa) fasta scores: E(): 4.6e-48, 58.17% id in 208 aa.
   
 0.950
sthA
Soluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
   
 0.949
nudC
Similar to Escherichia coli NADH pyrophosphatase NudC SWALL:NUDC_ECOLI (SWALL:P32664) (257 aa) fasta scores: E(): 2.2e-77, 70.42% id in 257 aa, and to Yersinia pestis NADH pyrophosphatase NudC SWALL:NUDC_YERPE (SWALL:Q8ZAQ5) (260 aa) fasta scores: E(): 1.3e-84, 75.87% id in 257 aa.
   
  0.948
pntA
Pyridine nucleotide transhydrogenase subunit-alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family.
     
 0.946
pntB
Pyridine nucleotide transhydrogenase subunit-beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
    
  0.944
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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