Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
sufAConserved hypothetical protein; Similar to Erwinia chrysanthemi SufA protein SufA SWALL:Q9EXP6 (EMBL:AJ301654) (123 aa) fasta scores: E(): 2.9e-33, 68.29% id in 123 aa, and to Escherichia coli SufA protein SufA or b1684 SWALL:SUFA_ECOLI (SWALL:P77667) (122 aa) fasta scores: E(): 3e-30, 67.52% id in 117 aa; Belongs to the HesB/IscA family. (123 aa)    
Predicted Functional Partners:
sufB
Conserved hypothetical protein; Similar to Erwinia chrysanthemi SufB protein SufB SWALL:Q9EXP5 (EMBL:AJ301654) (499 aa) fasta scores: E(): 1.6e-185, 88.6% id in 500 aa, and to Escherichia coli sufb protein SufB or b1683 SWALL:SUFB_ECOLI (SWALL:P77522) (495 aa) fasta scores: E(): 2.1e-176, 84.4% id in 500 aa.
  
 
 0.911
sufD
Conserved hypothetical protein; Similar to Escherichia coli SufD protein SufD or b1681 SWALL:SUFD_ECOLI (SWALL:P77689) (423 aa) fasta scores: E(): 1e-99, 61.5% id in 413 aa, and to Erwinia chrysanthemi SufD protein sSufD SWALL:Q9EXP3 (EMBL:AJ301654) (430 aa) fasta scores: E(): 1.6e-114, 69.78% id in 417 aa.
 
 
 0.835
sufC
Similar to Escherichia coli probable ATP-dependent transporter SufC or b1682 SWALL:SUFC_ECOLI (SWALL:P77499) (248 aa) fasta scores: E(): 2.7e-71, 85.08% id in 248 aa, and to Erwinia chrysanthemi SufC protein SufC SWALL:Q9EXP4 (EMBL:AJ301654) (248 aa) fasta scores: E(): 6.7e-72, 85.88% id in 248 aa.
  
 
 0.816
hscB
Chaperone protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
 
 
 0.810
fdx
Ferredoxin, 2Fe-2S; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri ferredoxin, 2fe-2s Fdx or b2525 or z3792 or ecs3391 or sf2572 SWALL:AAN44071 (EMBL:M88654) (111 aa) fasta scores: E(): 6.7e-39, 84.68% id in 111 aa.
 
 0.760
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
 
 
 0.753
icsU
NifU-like protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 
 0.751
nifU
Nitrogen fixation protein; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
  
 
 0.716
sufS
Selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo.
 
 
 0.700
iscR
Putative transcriptional regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.
  
  
 0.680
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.